|Title:||Circadian Variations of Atrial Natriuretic Peptide in Normal People and Its Relationship to Arterial Blood Pressure, Plasma Renin Activity and Aldosterone Level||Authors:||CHIANG, FU-TIEN
|Issue Date:||1994||Journal Volume:||v.46||Journal Issue:||n.3||Start page/Pages:||229-233||Source:||INTERNATIONAL JOURNAL OF CARDIOLOGY||Abstract:||
To investigate the circadian variations of plasma atrial matriuretic peptide (ANP) and its relationship to arterial blood pressure, plasma renin actitity and aldosterone level, we determind 24-h blood pressure in 14 healthy volunteers. Plasma ANP concentration, renin activity and aldosterone levels were measured every 3 h by radioimmunoassay. We found no significant circadian variation of plasma ANP level (pg/ ml)(daytime level, 62±24 vs. night-time level, 57±19, p=0 . 146) and plasma renin level(ng/ml/h)(1.32±0.78 vs. 1.15±0. 57, p=0.148), but there was diurnal change of blood pressure (mmHg)(systolic, 122±7 vs 116±11, p<0.001; diastolec, 80±11 vs. 72±11, p=0.025) and plasma aldosterone level (pg/ ml)(86±42 vs. 62±37, p<0.001). The blood pressure and aldosterone levels reached maxima(11:00 h and 08:00 h, respectively) before that of ANP (17: 00 h) and then decreased together until the nadir at 02:00 h. This might indicate that elevation of arterial blood pressure and plasma aldosterone level stimulate release of ANP under normal physiological conditions.#0041 #
|Appears in Collections:||醫學系|
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