https://scholars.lib.ntu.edu.tw/handle/123456789/202130
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 檢驗醫學科 | en |
dc.contributor.author | CHIANG, FU-TIEN | en |
dc.contributor.author | HSU, KWAN-LIH | en |
dc.contributor.author | TSENG, CHUEN-DEN | en |
dc.contributor.author | LO, HUEY-MING | en |
dc.contributor.author | CHERN, TSER-HAW | en |
dc.contributor.author | TSENG, YUNG-ZU | en |
dc.creator | 江福田;許寬立;曾春典;駱惠銘;陳澤浩;曾淵如 | zh-tw |
dc.creator | CHIANG, FU-TIEN;HSU, KWAN-LIH;TSENG, CHUEN-DEN;LO, HUEY-MING;CHERN, TSER-HAW;TSENG, YUNG-ZU | en |
dc.date | 1997 | en |
dc.date.accessioned | 2009-01-20T06:27:11Z | - |
dc.date.accessioned | 2018-07-12T09:11:23Z | - |
dc.date.available | 2009-01-20T06:27:11Z | - |
dc.date.available | 2018-07-12T09:11:23Z | - |
dc.date.issued | 1997 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/103253 | - |
dc.description.abstract | To study the association of renin gene polymorphism with essential hypertension in the Chinese population, 86 hypertensive and 107 normotensive subjects were enrolled from an epidemiologic survey. Leukocyte DNA was extracted and digested with Hind III and Bgl I restriction enzymes. Southern hybridization was done with digoxigenin- incorporated renin gene probes generated by polymerase chain reaction. The restriction fragments were detected by anti- digoxigenin antibody and enzyme methods. Two Hind III polymorphysms of the renin gene (8.7 kb and 6 .2 kb) were identified. The allele frequences were 129(75%) and 43(25%), respectively, in hypertensives; they were 139(65%) and 75( 35%), respectively, in normotensives(x = 4.074, p=0.044). The genotypes of 8.7/8 .7, 8.7/6.2 and 6.2/6.2 were significantly different between hypertensives and normotensives, being 45(52%), 39(45%), 2(3%) and 48(45%), 43 (40%), and 16(15%), respectively (x = 9.002, p=0.011). The Bgl I polymorphism did not show a difference between hypertensives and normotensives. Thus, we conclude that the renin gene Hind III polymorphysm is associated with hypertension in this Chinese population. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CLINICAL GENETICS v.51 n.6 pp.370-374 | en |
dc.relation.ispartof | CLINICAL GENETICS | - |
dc.title | Association of the Renin Gene Polymorphism with Essential Hypertension in a Chinese Population | en |
dc.relation.pages | 370-374 | - |
dc.relation.journalvolume | v.51 | - |
dc.relation.journalissue | n.6 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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