https://scholars.lib.ntu.edu.tw/handle/123456789/202160
DC Field | Value | Language |
---|---|---|
dc.contributor | 檢驗醫學科 | en |
dc.contributor.author | HSIUNG, CHAO A. | en |
dc.contributor.author | CHIANG, FU-TIEN | en |
dc.creator | 熊昭;江福田 | zh-tw |
dc.creator | HSIUNG, CHAO A.;CHIANG, FU-TIEN | en |
dc.date | 2001 | en |
dc.date.accessioned | 2009-01-20T06:34:38Z | - |
dc.date.accessioned | 2018-07-12T09:12:21Z | - |
dc.date.available | 2009-01-20T06:34:38Z | - |
dc.date.available | 2018-07-12T09:12:21Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/103319 | - |
dc.description.abstract | BACKGROUND: Several studies implicate polymorphisms in the human beta- adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area. METHODS: We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5' leader cistron; another C/T transition that results in a glycine/ arginine substitution at codon 16 ( Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln). RESULTS: The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95 % CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population . There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population. CONCLUSIONS: The Glyl6 allele in the beta2- adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | AMERICAN JOURNAL OF HYPERTENSION v.14 n.12 pp.1196-1200 | en |
dc.relation.ispartof | AMERICAN JOURNAL OF HYPERTENSION | - |
dc.subject | Hypertension | en |
dc.subject | blood pressure variation | en |
dc.subject | 2-adrenergic receptor | en |
dc.subject | association | en |
dc.subject | polymorphism | en |
dc.title | The Glycine Allele of a Glycine/Arginine Polymorphism in the Beta2- Adrenergic Receptor Gene Is Associated with Essential Hypertension in a Population of Chinese Origin | en |
dc.relation.pages | 1196-1200 | - |
dc.relation.journalvolume | v.14 | - |
dc.relation.journalissue | n.12 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
Appears in Collections: | 醫學系 |
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