https://scholars.lib.ntu.edu.tw/handle/123456789/202162
Title: | Raloxifene Versus Continuous Combined Estrogen/Progesterone Therapy: Densitometric and Biochemical Effects in Healthy Postmenopausal Taiwanese Women | Authors: | 蔡克嵩 TSAI, KEH-SUNG YEN, MENG-LUH PAN, HSIEN-AN WU, MENG-HSING HSU, SANDY HUEY-JEN CHENG, WERN-CHERNG YEN, BETTY LIN-JU |
Keywords: | BMD;Bone markers;HRT;Raloxifene;Serum lipids | Issue Date: | 2001 | Journal Volume: | v.12 | Journal Issue: | n.12 | Start page/Pages: | 1020-1025 | Source: | OSTEOPOROSIS INTERNATIONAL | Abstract: | We treated 116 healthy postmenopausal women (age 47-66 years , mean 57 years) in Taiwan with either raloxifene (RLX) 60 mg (n = 92) or 0.625 mg conjugated equine estrogen plus 5 mg medroxyprogesterone acetate (CCEP, n = 24) daily for 12 months in a randomized, double-masked, active- controlled fashion. The results showed that both regimens increased bone mineral density (BMD) at hip sites (means: RLX 2.5-4.9% , CCEP 4.6-7.9%, all p<0.005 compared with baseline), and the difference between the two regimens was not significant. The spinal BMD increased significantly in both groups (1.4% with RLX and 6.0% with CCEP, both p<0.01), and more with CCEP (p<0.003). Osteocalcin levels and urinary type I collagen C- telopeptide/creatinine ratios decreased significantly in both regimens, but the decreases were significantly larger with CCEP. Compared with baseline, both RLX and CCEP decreased the total cholesterol (median 4.9% and 8.6% respectively, p<0.001) and LDL-cholesterol (median 11% and 19% respectively, p<0.001), and increased HDL- cholesterol (median 8.6% and 10 .7% respectively, p<0.01). Both regimens increased triglyceride levels ( median 3.2% and 18.9% respectively, both p<0.05), although to a lesser extent with RLX than with CCEP (p<0.05). Only 3 subjects (3. 3%) reported vaginal bleeding in the RLX group, as compared with 31% (7/22) with CCEP ( p<0.05). We conclude that in healthy, postmenopausal Taiwanese women, RLX 60 mg given daily has favorable results in BMD, bone turnover and serum lipids, although the dosage we used showed a potency less than that of conventional CCEP. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/103323 |
Appears in Collections: | 醫學系 |
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