|Title:||Antimicrobial Resistance in Streptococcus Pneumoniae, Taiwan||Authors:||HSUEH, PO-REN
|Keywords:||PENICILLIN-RESISTANT;CEPHALOSPORIN-RESISTANT;HAEMOPHILUS- INFLUENZAE;BACTERIAL-MENINGITIS;CLONES;CHILDREN||Issue Date:||2002||Journal Volume:||v.8||Journal Issue:||n.12||Start page/Pages:||1487-1491||Source:||EMERGING INFECTIOUS DISEASES||Abstract:||
Taiwan has one of the highest levels of anti biotic- resistant pneumococcus in the world. Pneumococcal isolates not susceptible to penicillin first appeared in Taiwan in 1986; in 1995 an increase in the prevalence of nonsusceptibility to penicillins, extended-spectrum cephalosporins, trimethoprim-sulfamethoxazole, and macrolides as well as multidrug resistance began to be recognized. With the persistence of antibiotic selective pressure, resistance in some antibiotics reached a high plateau (P-lactam antibiotics) or continued to increase ( macrolides) , while novel resistance (fluoroquinolones) emerged in the last 3 years. Widespread distribution of some novel resistant 23F and 19F clones (and the international epidemic of 23F clones) contributes further to the rapid increase of resistance. Because Streptococcus pneumoniae is a major pathogen that causes community-acquired lower respiratory tract infections and meningitis in adults and children, antibiotic-resistance in this organism is a serious problem.
|Appears in Collections:||醫學系|
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