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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/202185
Title: Emergence of Nosocomial Candidemia at a Teaching Hospital in Taiwan from 1981 to 2000: Increased Susceptibility of Candida Species to Fluconazole
Authors: HSUEH, PO-REN
TENG, LEE-JENE
HO, SHEN-WU
YANG, PAN-CHYR
LUH, KWEN-TAY
Keywords: BLOOD-STREAM INFECTIONS;ANTIFUNGAL SUSCEPTIBILITY;ALBICANS;EPIDEMIOLOGY;SURVEILLANCE;RESISTANCE
Issue Date: 2002
Journal Volume: v.8
Journal Issue: n.4
Start page/Pages: 311-319
Source: MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE 
Abstract: 
The incidence of nosocomial Candida fungemia increased 36- fold from 1981 (0.8/10,000 discharges) to 2000 (28.8/10,000 discharges) at the National Taiwan University Hospital, a 2000-bed teaching hospital in northern Taiwan. To understand the current status of resistance to available antifungal agents among Candida species causing invasive infections, the in vitro susceptibilities of 222 isolates (collected from July, 1999-June, 2001) were determined. Among all of the Candida species tested, 6% and 7% were resistant to fluconazole and itraconazole, respectively. The MIC90 values of voriconazole and amphotericin B were 0.5 and 1 mug/ml, respectively, although some isolates of C. krusei ( amphotericin B and voriconazole MIC, >64 mug/ml) and C tropicalis and C. glabrata ( voriconazole MICs, >64 mug/ml) were less susceptible to voriconazole or amphotericin B. About one-half of the C glabrata isolates belonged to susceptible dose-dependent (SDD, 36%) or resistant (12%) categories for fluconazole and 96% belonged to SDD (56%) or resistant (40%) category for itraconazole. When compared with fluconazole susceptibility data of blood Candida isolates recovered from patients treated at the same hospital ( NTUH) from two different time periods (January, 1994, to June, 1995, and January, 1997, to June, 1999 described in previous reports), the incidence of increased susceptibility of non-krusei Candida isolates to fluconazole was evident. This trend of increasing susceptibility for fluconazole did not correlate to the increasing use of this agent in the hospital. None of the random amplified polymorphic DNA patterns generated by arbitrarily primed PCR using four random oligonucleotide primers for 14 isolates, which exhibited fluconazole MICs of greater than or equal to 16 mug/ml, were identical, indicating an absence of clonal dissemination among these isolates in the hospital.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/103369
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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