|Title:||Effect of Raloxifene, One of the Selective Estrogen Receptor Modulator, on Pituitary-Ovary Axis and||Authors:||蔡克嵩
HSU, SANDY HUEY-JEN
|Keywords:||Raloxifene;prolactin;FSH;LH||Issue Date:||2004||Journal Volume:||v.23||Journal Issue:||n.2-3||Start page/Pages:||215-218||Source:||ENDOCRINE||Abstract:||
To investigate the clinical effects of raloxifene, one of the selective estrogen receptor modulators (SERMs), on the pituitary–ovary axis and prolactin, a prospective, randomized, double-blinded study on 59 healthy postmenopausal women was performed. Forty-eight women received raloxifene 60 mg daily. The other 11 received combined conjugated equine estrogen 0. 625 mg and medroxyprogesterone acetate 5 mg daily (CCEP) as active controls. Serum follicle stimulating hormone (FSH), luteinizing hormone ( LH), estradiol (E2), and pro-lactin were measured at baseline and 1 yr after treatment. The mean levels of FSH and LH were significantly decreased in the raloxifene group (FSH: -10.7%; p < 0.01, LH: -10.3%; p < 0. 05) and CCEP group (FSH: -53.7%, p < 0.001; LH: -46.8%, p < 0.001). The prolactin level decreased in the raloxifene group but not in the CCEP group (-17.0%; p < 0.001 vs +13.3% , p = no significance; NS). Consequently, long-term administration of raloxifene up to 1 yr decreases serum prolactin level significantly and may be a therapeutic alternative for postmenopausal osteoporotic women with hyperprolactinemia.
|Appears in Collections:||醫學系|
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