Relationships between Antimicrobial Use and Antimicrobial Resistance in Gram-Negative Bacteria Causing Nosocomial Infections from 1991–2003 at a University Hospital in Taiwan

Abstract

國內婦女接受子宮切除的人數愈來愈多，而子宮切除後婦女的性生活適應，會影響到其自我認同與人際關係，是需要被重視的議題。本研究目的即在於了解子宮切除婦女性生活的一般經驗，並找出影響術後性生活適應的因素，並進一步以女性主義觀點檢視之。84位良性診斷子宮切除的婦女，在術後3-9個月後接受訪視，其中65位已婚且手術前仍有性生活。結果發現術後有九成的婦女已恢復性生活，其中7.8% 的人有點不滿意。比較手術前後對性生活滿意度的改變情形，有3.9% 變好，13.7%變差，82.4%不變。19.7%的人在術後第八週開始性行iprofloxacin-resistant E. coli and meropenem- resistant P. aeruginosa was significantly correlated with increased consumption of extended-spectrum cephalosporins, β-lactam–β-lactamase inhibitor combinations, carbapenems, fluoroquinolones and aminoglycosides (for ciprofloxacin-resistant E. coli and meropenem-resistant P. aeruginosa only) in the hospital ( Pearson's correlation coefficient, r > 0.72 (or < −0.72 ) and P-value < 0.05). Increased ciprofloxacin-resistant K. pneumoniae and meropenem-resistant Acinetobacter spp. was significantly associated with the increased usage of extended-spectrum cephalosporins but not with the other four classes of antibiotics. This 13-year study in a hospital demonstrated significant changes in antimicrobial use, which may have affected antimicrobial resistance in certain Gram- negative bacteria at the hospital.