|Title:||Directly Measured Insulin Resistance and the Assessment of Clustered Cardiovascular Risks in Hypertension||Authors:||LIN, MING-WEI
SHEU, WAYNE HUEY-HERNG
CHEN, YII-DER I.
|Keywords:||factor analysis;hypertension;insulin sensitivity;obesity||Issue Date:||2006||Journal Volume:||v.19||Journal Issue:||n.11||Start page/Pages:||1118-1124||Source:||AMERICAN JOURNAL OF HYPERTENSION||Abstract:||
Background: The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test ( IST), to a clustering of cardiovascular risk factors in hypertensive subjects. Methods: A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects. Results: In factor analysis, SSPG aggregated with metabolic variables in an obesity- hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38. 3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors : one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%). Conclusions: Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant.
|Appears in Collections:||醫學系|
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