https://scholars.lib.ntu.edu.tw/handle/123456789/202425
標題: | Teriparatide Vs. Calcitonin in the Treatment of Asian Postmenopausal Women with Established Osteoporosis | 作者: | 蔡克嵩 HWANG, J-S TSAI, KEH-SUNG |
關鍵字: | teriparatide;calcitonin;osteoporosis;bone mineral density | 公開日期: | 2006 | 卷: | v.17 | 期: | n.3 | 起(迄)頁: | 373-378 | 來源出版物: | OSTEOPOROS INTERNATIONAL | 摘要: | This study compared the clinical efficacy, safety, and tolerability of daily subcutaneous injections of teriparatide and salmon calcitonin in the treatment of postmenopausal women with established osteoporosis in Taiwan . This 6-month, multicenter, randomized, controlled study enrolled 63 women with established osteoporosis. They were randomized to receive either teriparatide 20 microg or calcitonin 100 IU daily in an open-label fashion. Lumber spine, femoral neck, total hip bone mineral density (BMD), and biochemical markers of bone turnover were measured, and adverse events and tolerability were recorded. The results at 6 months showed that patients using teriparatide had larger mean increases in spinal BMD than those who used calcitonin (4.5% vs. 0.1%), but the BMD changes in these two groups at the femoral neck and the total hip were not significant. There were also larger mean increases in bone markers in the teriparatide group than in the calcitonin group (bone specific alkaline phosphatase 142 % vs. 37%; osteocalcin 154% vs. 23%). We conclude that teriparatide has more positive effects on bone formation than salmon calcitonin, as shown by the larger increments of lumbar spine BMD and bone formation markers, and caused only mild adverse events and no significant change in liver, kidney or hematological parameters. Compared with the published global results, teriparatide seems to be equally effective and safe to use in this Asian population. at 6 months showed that patients using teriparatide had larger mean increases in spinal BMD than those who used calcitonin (4 .5% vs. 0.1%) , but the BMD changes in these two |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/94633 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。