In Vitro Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli Isolated from Patients with Intra-Abdominal Infections in the Asia -Pacific Region: 2004 Results from Smart (Study for Monitoring Antimicrobial Resistance Trends)

Abstract

In the 2004 Study for Monitoring Antimicrobial Resistance Trends (SMART), 14 centres from six countries in Asia- Pacific collected 1198 unique aerobic and facultative Gram- negative bacilli from intra-abdominal infections for susceptibility testing to 12 antimicrobial agents. Enterobacteriaceae comprised 82% of the total isolates. Escherichia coli was the most commonly isolated species (43% ). Resistance rates were generally higher in Enterobacteriaceae isolated from Asian centres than those isolated from Oceania centres. There was little difference in susceptibility rates between community- and hospital- acquired Enterobacteriaceae for carbapenems. Extended- spectrum beta-lactamase ( ESBL)-producers typically had a more resistant profile than non-ESBL- producers, but were usually susceptible to carbapenems. Of the antimicrobial agents tested, carbapenems were the most reliably active in vitro against Enterobacteriaceae recovered from patients in Asia-Pacific with intra-abdominal infections. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.