|Title:||Changes in Macrolide Resistance among Respiratory Pathogens after Decreased Erythromycin Consumption in Taiwan||Authors:||HSUEH, PO-REN
|Keywords:||Anti-Bacterial Agents/ pharmacology;Azithromycin/ pharmacology;Bacterial Infections/drug therapy;Comparative Study;Drug Resistance, Bacterial;Drug Utilization||Issue Date:||2006||Journal Volume:||v.12||Journal Issue:||n.3||Start page/Pages:||296-298||Source:||CLINICAL MICROBIOLOGY AND INFECTION||Abstract:||
Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0. 001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs . 0% in 2003; p < 0.001). However, the rate of erythromycin resistance in Streptococcus pneumoniae showed a continued increase, from 80.2% in 1999 to 92% in 2003.
|Appears in Collections:||醫學系|
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