Changes in Macrolide Resistance among Respiratory Pathogens after Decreased Erythromycin Consumption in Taiwan
Resource
CLINICAL MICROBIOLOGY AND INFECTION v.12 n.3 pp.296-298
Journal
CLINICAL MICROBIOLOGY AND INFECTION
Journal Volume
v.12
Journal Issue
n.3
Pages
296-298
Date Issued
2006
Date
2006
Author(s)
HSUEH, PO-REN
SHYR, JAINN-MING
WU, JIUNN-JONG
Abstract
Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0. 001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs . 0% in 2003; p < 0.001). However, the rate of erythromycin resistance in Streptococcus pneumoniae showed a continued increase, from 80.2% in 1999 to 92% in 2003.
Subjects
Anti-Bacterial Agents/ pharmacology
Azithromycin/ pharmacology
Bacterial Infections/drug therapy
Comparative Study
Drug Resistance, Bacterial
Drug Utilization