https://scholars.lib.ntu.edu.tw/handle/123456789/202444
Title: | Nationwide Surveillance in Taiwan of the in-Vitro Activity of Tigecycline against Clinical Isolates of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae | Authors: | LU, DANIEL C-T CHUANG, YIN-CHING LIU, YUNG-CHING JANG, TSRANG-NENG LU, PO-LIANG CHEN, CHIH-MING HSU, GWO-JONG HSUEH, PO -REN |
Keywords: | Tigecycline;Extended-spectrum beta-lactamase;Etest;Broth microdilution;Taiwan;Enterobacteriaceae | Issue Date: | 2008 | Journal Volume: | v.32 | Journal Issue: | 183 | Start page/Pages: | - | Source: | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | Abstract: | Tigecycline In-vitro Surveillance in Taiwan (TIST), initiated in 2006, is a nationwide surveillance programme designed to monitor longitudinally the in-vitro activity of tigecycline against commonly encountered resistant bacteria. This study compared the in-vitro activity of tigecycline against clinical isolates of resistant Gram-negative bacteria determined by the broth microdilution and Etest methods. A total of 622 isolates were collected from patients treated at 20 teaching hospitals. Tigecycline had excellent in-vitro activity against extended-spectrum beta - lactamase (ESBL)-producing Escherichia coli (N = 275) with MIC90 0.5 mu g/mL and a 99.6% susceptibility rate, and also against ESBL-producing Klebsiella pneumoniae ( N = 324) with MIC90 2 mu g/mL and a 98.5% susceptibility rate. For ESBL- producing Proteus mirabilis (N = 15) the MIC90 was 4 mu g/mL with a 73.3% susceptibility rate. For ESBL-producing Klebsiella oxytoca (N = 8) the MIC50 and MIC90 were 0.5 and 1 mu g/mL, respectively, with a 100% susceptibility rate. Limited agreement (< 80%) was found between the broth microdilution and the Etest methods when determining the in- vitro activity of tigecycline against ESBL-producing K . pneumoniae and K. oxytoca. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/175390 |
Appears in Collections: | 醫學系 |
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