Resveratrol在減輕大花鼠腦梗塞及再灌注性傷害中抑制嗜中性白血球黏著之發炎現象的影響
Date Issued
2002
Date
2002
Author(s)
蔡勝國
DOI
902314B002400
Abstract
Resveratrol, a natural phytoalexin
(3,5,4’-trihydroxystilbene), is present in the
seeds and skin of grapes and constitutes one of
the major components of red wine. In
previously study, we found that resveratrol is a
potent neuroprotective agent on rats subjected
to focal cerebral ischemia. The present study
was undertaken to evaluate the lactate
dehydrogenase (LDH) activity in plasma and to
study the neutrophil infiltration in the brain
after right middle cerebral artery was occluded
for 1 hr and reperfusion for 24 hr in
anesthetized Long-Evans rats. Compared with
control groups, it revealed that pretreatment or
treatment resveratrol groups, the LDH levels
was decreased in plasma. In addition,
compared with control groups, the change in
cerebral myeloperoxidase (MPO) activity, a
biochemical marker of neutrophil infiltration,
which was considerably increased following
focal cerebral ischemia and reduced by
resveratrol pretreatment and treatment groups.
We further examine whether on neutrophil
resveratrol could prevent
phorbol-12-myristae-13-acetate (PMA) and
N-formyl-methionyl-leucyl-phenylalanine
(fMLP) induced reactive oxygen species (ROS)
production. Results demonstrated that PMA
and fMLP induced rapid accumulation of
H2O2 in neutrophils within 30 minutes.
Resveratrol decreased the accumulation of the
oxygen radical metabolites. These data suggest
that resveratrol is a potent neuroprotective
agent in focal cerebral ischemia. Its beneficial
effects may be part related to its
anti-inflammatory.
Subjects
resveratrol, red wine, stroke, focal cerebral
ischemia, neutrophil
ischemia, neutrophil
Publisher
臺北市：國立臺灣大學醫學院麻醉科
Type
journal article
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