DC 欄位 | 值 | 語言 |
dc.contributor.author | 孫維仁 | zh-TW |
dc.creator | 孫維仁 | zh_TW |
dc.date | 2003 | zh_TW |
dc.date.accessioned | 2006-07-26T05:41:59Z | - |
dc.date.accessioned | 2018-07-13T07:08:44Z | - |
dc.date.available | 2006-07-26T05:41:59Z | - |
dc.date.available | 2018-07-13T07:08:44Z | - |
dc.date.issued | 2003 | - |
dc.identifier | 912314B002241 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/28870 | - |
dc.description.abstract | Although induction of deep aching sensation, De-Qi, is generally accepted as a
standard acupunctural practice, whether an intense nociceptive stimulation is required
for optimal analgesic effect remains controversial. In freely moving rats we first
demonstrated that intramuscular injection of 100 μl 5% formalin, a noxious irritant, in
the Zusanli acupoint (ST-36) induced intense nociceptive behavior. Tail-flick latency
and c-fos expression were then compared among halothane-anesthetized rats receiving
either low-intensity electroacupuncture (10× threshold of local muscle contraction),
high-intensity (20× threshold) electroacupuncture (30 min, 4Hz), intramuscular formalin,
or normal saline injection at the right Zusanli acupoint. We found that formalin injection
at the acupoint markedly increased tail-flick latency and induced greater c-fos
expression at the superficial and deep laminae of spinal cord dorsal horn compared to
saline injection. Electroacupuncture prolonged the cumulative tail-flick latency in an
intensity-dependent manner but, in contrast to formalin, did not provide intensity
sufficient to induce c-fos expression throughout the 2nd to 5th lumbar segments. Our
data indicated that although noxious chemical stimulation at the acupoint can elicit
comparable analgesic effect, non-noxious electrical stimulations produce even greater
analgesic responses in an intensity-dependent manner. These findings suggest that
generation of intense aching sensation, De-Qi, is not required for the analgesic effect
provided by electroacupuncture. | en |
dc.format | application/pdf | en |
dc.format.extent | 132157 bytes | - |
dc.format.mimetype | application/pdf | en |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院麻醉科 | zh_TW |
dc.rights | 國立臺灣大學醫學院麻醉科 | zh_TW |
dc.subject | electroacupuncture, tail flick, formalin, c-fos expression, stimulation
intensity, anesthesia | en |
dc.title | 調控脊髓基因對於針刺痛之影響(第三年) | zh_TW |
dc.type | journal article | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/28870/1/912314B002241.pdf | - |
dc.coverage | 計畫年度:91;起迄日期:2002-08-01/2003-10-31 | zh_TW |
item.languageiso639-1 | zh_TW | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
顯示於: | 醫學系
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