|Title:||New Bioactive Clerodane Diterpenoids from the Roots of Casearia membranacea||Authors:||Chen, Ching-Yu
Khalil, Ashraf Taha
|Issue Date:||2008||Journal Volume:||v.5||Journal Issue:||n.1||Start page/Pages:||162-167||Source:||Chemistry & Biodiversity||Abstract:||
Bioassay-guided fractionation of the acetone extract of the roots of Casearia membranacea furnished three new clerodane diterpenes, caseamembrins S-U (1-3) and the known caseamembrin Q (4). Their structures were established by extensive spectroscopic analyses, especially 2D-NMR. Compounds 1-4 were tested against human tumor cells, including HeLa ( cervical epitheloid carcinoma), DLD-1 (colon carcinoma), Daoy ( medulloblastoma), and KB (oral epidermoid carcinoma) cell lines. Caseamembrin T (2) exhibited the most potent activity against Daoy cells ( ED50 = 10 ng/ml), superior to that of the standard drug mitomycin.
|Appears in Collections:||醫學系|
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