https://scholars.lib.ntu.edu.tw/handle/123456789/203658
標題: | New Bioactive Clerodane Diterpenoids from the Roots of Casearia membranacea | 作者: | Chen, Ching-Yu Cheng, Yuan-Bin Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Guh, Jih-Hwa Khalil, Ashraf Taha Shen, Ya-Ching |
公開日期: | 2008 | 卷: | v.5 | 期: | n.1 | 起(迄)頁: | 162-167 | 來源出版物: | Chemistry & Biodiversity | 摘要: | Bioassay-guided fractionation of the acetone extract of the roots of Casearia membranacea furnished three new clerodane diterpenes, caseamembrins S-U (1-3) and the known caseamembrin Q (4). Their structures were established by extensive spectroscopic analyses, especially 2D-NMR. Compounds 1-4 were tested against human tumor cells, including HeLa ( cervical epitheloid carcinoma), DLD-1 (colon carcinoma), Daoy ( medulloblastoma), and KB (oral epidermoid carcinoma) cell lines. Caseamembrin T (2) exhibited the most potent activity against Daoy cells ( ED50 = 10 ng/ml), superior to that of the standard drug mitomycin. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/173126 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。