The study of risk factors for coronary heart disease in men with spinal cord injury
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
王顏和
DOI
932314B002119
Abstract
Aim: To identify the associated risk
factors for cardiovascular disease in
male patients with spinal cord injury
(SCI) and to study their determinants of
carotid atherosclerosis.
Material and Methods: Eighty-seven
male patients with traumatic SCI were
recruited. After overnight fasting for 10
hours, baseline venous blood sample
was obtained and then a 75-g oral
glucose tolerance test (OGTT) was
performed for each patient. HP 4500
SONOS carotid ultrasound equipped
with 3-10 MHz high-resolution real-time
M-mode and 3.6 MHz Doppler was also
performed for each patient. Baseline
lipid profile, serum inflammatory
marker (hs-CRP) and blood glucose and
insulin levels before and after OGTT
were used to evaluate the associations
with carotid intima-media thickness
(IMT) in different segments of common
carotid arteries (CCA). Multivariate
regression analysis with mixed models
was used to evaluate the associated
determinants of CCA IMT.
Results: Post-load 2-h glucose levels
and glucose area under curve after
OGTT were found as important
determinants for CCA IMT in different
segments. In addition to age, body mass
index (BMI) also was identified as
important determinant for carotid IMT.
However, office systolic and diastolic
blood pressures were not significant
predictor for CCA IMT.
Conclusion: OGTT identified glucose
level at 120 minutes and BMI are two
most important determinants for carotid
atherosclerosis in male SCI patients. To
2
prevent cardiovascular disease in SCI
subjects, exercise and weight control
should be emphasized.
Subjects
Spinal cord injury
carotid intima-media-thickness
oral glucose tolerance test
SDGs
Publisher
臺北市：國立臺灣大學醫學院復健科
Type
other
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