https://scholars.lib.ntu.edu.tw/handle/123456789/204751
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 骨科 | en |
dc.contributor.author | CHIU, YUNG-CHENG | en |
dc.contributor.author | YANG, RONG-SEN | en |
dc.contributor.author | HSIEH, KUO-HSIEN | en |
dc.contributor.author | FONG, YI-CHIN | en |
dc.contributor.author | WAY, TZONG-DER | en |
dc.contributor.author | LEE, TU-SHENG | en |
dc.contributor.author | WU, HSI-CHIN | en |
dc.contributor.author | FU, WEN-MEI | en |
dc.contributor.author | TANG, CHIH-HSIN | en |
dc.creator | 邱詠証;楊榮森;謝國顯;馮逸卿;魏宗德;李土生;吳錫芩;符文美;湯智昕 | zh_TW |
dc.creator | CHIU, YUNG-CHENG;YANG, RONG-SEN;HSIEH, KUO-HSIEN;FONG, YI-CHIN;WAY, TZONG-DER;LEE, TU-SHENG;WU, HSI-CHIN;FU, WEN-MEI;TANG, CHIH-HSIN | en |
dc.date | 2007 | en |
dc.date.accessioned | 2008-12-22T01:26:24Z | - |
dc.date.accessioned | 2018-07-13T09:09:34Z | - |
dc.date.available | 2008-12-22T01:26:24Z | - |
dc.date.available | 2018-07-13T09:09:34Z | - |
dc.date.issued | 2007 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/92434 | - |
dc.description.abstract | ABSTRACT The production of chemokine stromal cell-derived factor(SDF)-1 is significantly higher in synovial fluid of patients with osteoarthritis and rheumatoid arthritis. Matrix metalloproteinase (MMP)-13 may contribute to the breakdown of articular cartilage during arthritis. Here, we found that SDF-1 cultured human chondrocytes, as shown by reverse transcriptase- polymerase chain reaction, Western blot, and zymographic analysis. SDF-1 expression of CXCR4 receptor in human chondrocytes. CXCR4- neutralizing antibody , CXCR4-specific inhibitor [1-[[4-(1,4, 8,11- tetrazacyclotetradec-1-ylmethyl)phenyl] methyl]-1,4,8,11- tetrazacyclotetradecane (AMD3100)], or small interfering RNA against CXCR4 inhibited the SDF-1 induced increase of MMP- 13 expression. The transcriptional regulation of MMP-13 by SDF-1 phosphorylation of extracellular signal-regulated kinases ( ERK) and activation of the activator protein (AP)- 1 components of c-Fos and c-Jun. The binding of c- Fos and c - Jun to the activator protein (AP-1) element on the MMP-13 promoter and the increase in luciferase activity was enhanced by SDF-1 mutant of ERK2 or c-Fos and c-Jun antisense oligonucleotide inhibited the potentiating action of SDF-1 results provide evidence that SDF-1 activate ERK and the downstream transcription factors (c-Fos and c-Jun), resulting in the activation of AP-1 on the MMP- 13 promoter and contributing cartilage destruction during arthritis. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | MOLECULAR PHARMACOLOGY v.72 n.3 pp.695-703 | en |
dc.relation.ispartof | MOLECULAR PHARMACOLOGY | - |
dc.subject | STIMULATES FIBRONECTIN EXPRESSION | en |
dc.subject | SIGNAL-REGULATED KINASES-1/2 | en |
dc.subject | RHEUMATOID-ARTHRITIS | en |
dc.subject | CHEMOKINE RECEPTOR-4 | en |
dc.subject | PHOSPHOLIPASE-C | en |
dc.subject | CARCINOMA-CELLS | en |
dc.title | Stromal Cell-Derived Factor-1 Induces Matrix Metalloprotease-13 Expression in Human Chondrocytes | en |
dc.relation.pages | 695-703 | - |
dc.relation.journalvolume | v.72 | - |
dc.relation.journalissue | n.3 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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