Effect of human calcitonin on the secretion of luteinizing hormone in orchiectomized rats
Resource
CHINESE JOURNAL OF PHYSIOLOGY v.37 n.3 pp.161-163
Journal
Chinese Journal of Physiology
Journal Volume
v.37
Journal Issue
n.3
Pages
161-163
Date Issued
1994
Date
1994
Author(s)
CHEN, JIANN-JONG
TSAI, SHIOW-CHWEN
LU, CHIEN-CHEN
LEE, KUN-YEE
CHIEN, CHAU-HENG
TSAI, CHING-LIN
WANG, PAULUS, S
CHIEN, EILEEN, JEA
Abstract
The effect of human calcitonin (hCT) on the secretion of luteinizing hormone (LH) was examined in castrated rats. Male rats were orchiectomized(Orch) 2 weeks before they were treated with a single bolus injection of gonadotropin- releasing hormone (GnRH, 1 mk/kg of body dweight), hCT (3.4 ng/kg), or the combination of GnRH and hCT through a right jugular vein catheter. Blood sampoles (0.5 ml each time) were collected immeiately before (0-min) and then at 15, 30, 60,120 and 180 min after hormone infection. Plasma LH concentration was measured with a radioimmunoassay technique. Plasma calcium concentration was determined in an automatic analyzer. hCT singificantly diminished both the basal and GnRH-stimulated levels of pllasma LH without any relation to the reduced plasma levels of calcium. These results clearly demonstrated a plasma calcium- unrelated inhibitory effect of hCT on LH secretion. #2279#