|Title:||Effect of human calcitonin on the secretion of luteinizing hormone in orchiectomized rats||Authors:||陳俊忠
WANG, PAULUS, S
CHIEN, EILEEN, JEA
|Issue Date:||1994||Journal Volume:||v.37||Journal Issue:||n.3||Start page/Pages:||161-163||Source:||Chinese Journal of Physiology||Abstract:||
The effect of human calcitonin (hCT) on the secretion of luteinizing hormone (LH) was examined in castrated rats. Male rats were orchiectomized(Orch) 2 weeks before they were treated with a single bolus injection of gonadotropin- releasing hormone (GnRH, 1 mk/kg of body dweight), hCT (3.4 ng/kg), or the combination of GnRH and hCT through a right jugular vein catheter. Blood sampoles (0.5 ml each time) were collected immeiately before (0-min) and then at 15, 30, 60,120 and 180 min after hormone infection. Plasma LH concentration was measured with a radioimmunoassay technique. Plasma calcium concentration was determined in an automatic analyzer. hCT singificantly diminished both the basal and GnRH-stimulated levels of pllasma LH without any relation to the reduced plasma levels of calcium. These results clearly demonstrated a plasma calcium- unrelated inhibitory effect of hCT on LH secretion. #2279#
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.