https://scholars.lib.ntu.edu.tw/handle/123456789/204947
Title: | Effect of human calcitonin on the secretion of luteinizing hormone in orchiectomized rats | Authors: | CHEN, JIANN-JONG TSAI, SHIOW-CHWEN LU, CHIEN-CHEN LEE, KUN-YEE CHIEN, CHAU-HENG TSAI, CHING-LIN WANG, PAULUS, S CHIEN, EILEEN, JEA |
Issue Date: | 1994 | Journal Volume: | v.37 | Journal Issue: | n.3 | Start page/Pages: | 161-163 | Source: | Chinese Journal of Physiology | Abstract: | The effect of human calcitonin (hCT) on the secretion of luteinizing hormone (LH) was examined in castrated rats. Male rats were orchiectomized(Orch) 2 weeks before they were treated with a single bolus injection of gonadotropin- releasing hormone (GnRH, 1 mk/kg of body dweight), hCT (3.4 ng/kg), or the combination of GnRH and hCT through a right jugular vein catheter. Blood sampoles (0.5 ml each time) were collected immeiately before (0-min) and then at 15, 30, 60,120 and 180 min after hormone infection. Plasma LH concentration was measured with a radioimmunoassay technique. Plasma calcium concentration was determined in an automatic analyzer. hCT singificantly diminished both the basal and GnRH-stimulated levels of pllasma LH without any relation to the reduced plasma levels of calcium. These results clearly demonstrated a plasma calcium- unrelated inhibitory effect of hCT on LH secretion. #2279# |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/99077 |
Appears in Collections: | 醫學系 |
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