|Title:||Subacute effects of hematological and ventilatory adaptations on maximal oxygen uptake after expedition to Peak Lenin
|Keywords:||maximal oxygen uptake;erythropoietin;最大攝氧量;紅血球生成素||Issue Date:||2008||Journal Volume:||v.34||Journal Issue:||n.1||Start page/Pages:||41-50||Source:||Minghsin Journal||Abstract:||
Abstract The adaptations to high altitudes or hypoxia have mixed effects on the maximal oxygen uptake (V‧O2max) at sea level. This study investigated the change of V ‧ O2max, and the possible hematological and ventilatory adaptation mechanisms, after returning from a 17-day expedition to Peak Lenin (7134 m). Four mountaineers (three males and one female) were recruited. Hematological parameters, serum erythropoietin ( EPO), V ‧ O2max, and maximal ventilation were measured by Bruce protocol at baseline (20 days before arriving at the base camp) and eight days after their return. Serum EPO was also measured immediately after returning from the summit. The results were shown that absolute V ‧ O2max did not change, while V ‧O2max relative to body weight, maximal ventilation, and ventilation threshold increased significantly (p<.05) after the expedition. Serum EPO marginally increased by 36.52±22.36% (p=0 .053) during the expedition, then significantly decreased by 39.78±5.78% (p<.05) after return to sea level. Hematocrit and mean corpuscular volume (MCV) significantly elevated, while mean corpuscular hemoglobin concentration (MCHC) significantly (p<.05) decreased after the expedition. Hemoglobin was shown a trend of increase (15.0±1.6 vs 15.8±1.5 g/dl, p= 0.085) after the expedition. The two subjects have higher serum concentration in EPO than others. It showed the elevation in hemoglobin levels and V ‧ O2max. This study suggested that relative V ‧ O2max increased after returning from a high-altitude expedition. The increase in V‧ O2max at least partially resulted from hematological and ventilatory adaptations.
高山的低壓低氧環境，影響登山隊員最大攝氧量改變的生理因素十分複雜。本研究以攀登7134公尺高的勒寧峰，共有三男一女等四名隊員，在高地停留十七天後，測定隊員登山前後最大攝氧量、血液常規值、紅血球生成素(EPO)濃度、肺換氣量、換氣閾值等之改變。同時以布魯斯程式(Bruce protocol)測定登山前（抵達營地前二十天）與登山後（下山後八天）最大攝氧量、最大換氣量的改變來探討高山環境對隊員所引起的運動生理、生化功能變化。登山後隊員的最大攝氧量(VO(下標 2max) relative to B. W.), 最大換氣量、換氣閾值，有明顯增加的現象(p<.05)，體內紅血球生成素(EPO)增加，但下山後八天，則恢復至正常值。血球容積比(Hct, p<.05)，平均血球體積(MCV, p<.05)與血色素(Hb)皆有增高的情形，平均血球容積比(MCHC, p<.05)則顯著下降。其中有兩位隊員EPO、Hb與VO(下標 2max)更呈現較高的生理現象。攀登勒寧峰隊員於登山後，其相對最大攝氧量呈現增高，係由於身體恆定作用造成血液學（MCV, Hct, Hb, MCH, EPO等）數值，肺換氣量與換氣閾值皆呈現增加。
|Appears in Collections:||醫學系|
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