https://scholars.lib.ntu.edu.tw/handle/123456789/205565
標題: | Effects of Mephenoxalone and Tizanidine for Acute Painful Spasm of Paravertebral Muscles: A Randomized Double-Blind Control Study Mephenoxalone與tizanidine對脊椎周邊肌肉急性疼痛痙攣治療效果比較之隨機雙盲控制試驗 |
作者: | HOU, SHENG-MOU YANG, SHU-HUA WANG, JYH-HORNG 侯勝茂 楊曙華 王至弘 |
關鍵字: | spasm;paravertebral muscles;low back pain;mephenoxalone;tizanidine | 公開日期: | 2010 | 卷: | v.27 | 期: | n.1 | 起(迄)頁: | 1-9 | 來源出版物: | JOURNAL OF ORTHOPEDIC SURGERY TAIWAN | 摘要: | Objectives: Skeletal muscle relaxants are frequently used to treat low back pain with spasm of paravertebral muscles. However, there is little comparative efficacy and safety data of different muscle relaxants. A randomized, doubleblind study was conducted to evaluate and compare the efficacy and safety of mephenoxalone and tizanidine in the 7 -day treatment of adult patients suffering from acutely painful and moderately severe spasm of paravertebral muscles . Methods: A total of 41 Taiwanese patients were randomly allocated into mephenoxalone and tizanidine groups. Primary( muscle spasm severity, treatment responses) and secondary efficacy variables were obtained before and after treatments . Adverse events and several safety assessments were also recorded. Results: In a three item scale, muscle spasm severity was reduced by 0.90 0.55 and 0.95 0.67 points in the mephenoxalone and tizanidine groups, respectively. There was no significant difference between the two treatment groups in all variables for primary and secondary efficacy assessments. Nine mild to moderate adverse events were reported and one tizanidine-treated patient stopped the medication due to drug-induced urticaria. Transient slight drowsiness experienced in four mephenoxalone-treated patients did not hinder the treatment effect. Conclusion: This randomized, double-blind study demonstrates equivalent treatment efficacies of mephenoxalone and tizanidine in alleviating symptoms of acute painful paravertebral muscle spasms in Taiwanese patients. Both drugs with generally well tolerated. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/241727 |
顯示於: | 醫學系 |
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