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  4. Fractal analysis of nuclear medicine images for the diagnosis of pulmonary emphysema: Interpretations, implications, and limitations
 
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Fractal analysis of nuclear medicine images for the diagnosis of pulmonary emphysema: Interpretations, implications, and limitations

Journal
American Journal of Roentgenology
Journal Volume
174
Journal Issue
4
Pages
1055-1059
Date Issued
2000
Author(s)
Huang, Y.-H.
HSIAO-WEN CHUNG  
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034112338&doi=10.2214%2fajr.174.4.1741055&partnerID=40&md5=9e6781d31d2760e099db1f484694ef44
http://scholars.lib.ntu.edu.tw/handle/123456789/289953
Abstract
OBJECTIVE. The purpose of this study was to investigate, on images obtained in nuclear medicine examinations, the physical meanings and consequent implications of fractal analysis developed in a recent study that was reported to be effective in quantifying the heterogeneous distribution of carbon particle radioaerosol in the lungs. MATERIALS AND METHODS. Fractal dimensions were computed for 108 sets of radionuclide imaging data from 28 patients according to the methods in a previous report, and were then correlated with the ratio of tissue areas segmented at two thresholds (15% and 35% of maximal radioactivity). RESULTS. Fractal dimension was found to linearly correlate with the ratio natural logarithm of tissue areas segmented at two different threshold levels (n = 108, r = 0.994), with regression slope accurately predicted (error = 0.06%). Bland-Altman analysis showed that fractal dimensions ranging from 0.2 to 1.9 can be explained by this area ratio with disagreement of only 5.13% at two standard deviations; thus, fractal dimension seems to be an oversimplified parameter unrelated to spatial heterogeneity of radioaerosol distribution. CONCLUSION. The analysis of this study suggested that the fractal dimension defined in a previous report was limited to the indication of the percentage area of low- radioactivity regions with respect to total tissue area in the image. Because the fractal dimension partially reflects, but is not specific to, a certain degree of focal spots of low radioactivity, we suggest using fractal analysis in clinical practice only with careful control and thorough understanding of the physical meanings.
Other Subjects
carbon; erythrocyte tc 99m; hexamethylpropylene amine oxime technetium tc 99m; aerosol; article; clinical article; clinical trial; controlled clinical trial; controlled study; double blind procedure; drug distribution; fractal analysis; human; image analysis; liver scintiscanning; lung emphysema; lung scintiscanning; nuclear medicine; priority journal; radioactivity; randomized controlled trial; single photon emission computer tomography
Type
journal article

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