Some specific human leukocyte antigen (HLA)-DR/DQ haplotypes are more important than individual HLA-DR and -DQ phenotypes for the development of mucocutaneous type of Behçet's disease and for disease shift from recurrent aphthous stomatitis to mucocutaneous type of Behçet's disease
Journal
Journal of Oral Pathology and Medicine
Journal Volume
30
Journal Issue
7
Pages
402-407
Date Issued
2001
Author(s)
Abstract
The phenotype and haplotype frequencies of human leukocyte antigens (HLA)-DR and -DQ in 32 Chinese patients with the mucocutaneous (MC) type of Beh?et's disease (BD) were calculated and compared with those in 310 healthy control Chinese and with those in 80 Chinese patients with recurrent aphthous stomatitis (RAS). We found that the phenotype frequency of HLA-DRw8 [corrected P (Pc)<0.005] and the haplotype frequencies of HLA-DRw8/DQw1 (Pc<0.005), -DRw8/DQw5(w1) (Pc<0.0005), -DRw12(5)/DQw1 (Pc<0.005), -DRw12(5)/DQw6(w1) (Pc<0.0005), and -DRw52/DQw1 (Pc<0.005) in patients with the MC type of BD were significantly greater than those in healthy control subjects. This finding suggests that individual Chinese with HLA-DRw8 antigen and HLA-DRw8/DQw1, -DRw8/DQw5(w1), -DRw12(5)/DQw1, -DRw12(5)/DQw6(w1) and -DRw52/DQw1 haplotypes are more likely to have the MC type of BD. Furthermore, the relative risks (RRs) of HLA-DRw8/DQw1 (5.6), -DRw8/DQw5 (w1) (10.0), and -DRw12(5)/DQw6(w1) (14.4) haplotypes in patients with the MC type of BD were equal to or higher than the RR of HLA-DRw8 phenotype (5.6), suggesting that some of the HLA-DR/DQ haplotypes may play more important roles than the individual HLA-DR and -DQ phenotypes for the development of the MC type of BD. The phenotype frequencies of HLA-DR5 (Pc<0.01), -DRw8 (Pc<0.005) and -DQw1 (Pc<0.05) as well as the haplotype frequencies of HLA-DR5/DQw1 (Pc<0.005) and -DRw8/DQw1 (Pc<0.00005) in patients with the MC type of BD were significantly higher than those in patients with RAS. Moreover, the RRs of HLA-DR5/DQw1 (29.1) and -DRw8/DQw1 (47.4) haplotypes were greater than the RRs of HLA-DR5 (10.4), -DRw8 (23.4) and -DQw1 (4.0) antigens. These results suggest that some specific HLA-DR/DQ haplotypes may be more important than the individual HLA-DR and -DQ phenotypes in the disease shift from RAS to the MC type of BD.
Subjects
Beh?et's disease; Chinese; HLA-DR/DQ haplotypes
SDGs
Other Subjects
HLA DQ antigen; HLA DQ1 antigen; HLA DQw5; HLA DQw6; HLA DR antigen; HLA DR8; HLA DRw12; HLA DRw52; HLA-DQw5; HLA-DQw6; HLA-DR8; HLA-DRw12; HLA-DRw52; adolescent; adult; aged; algorithm; aphthous stomatitis; article; Behcet disease; chi square distribution; child; China; comparative study; female; genetics; haplotype; human; male; middle aged; phenotype; recurrent disease; risk; risk factor; statistics; Adolescent; Adult; Aged; Algorithms; Behcet Syndrome; Chi-Square Distribution; Child; China; Female; Haplotypes; HLA-DQ Antigens; HLA-DR Antigens; Humans; Male; Middle Aged; Odds Ratio; Phenotype; Recurrence; Risk Factors; Statistics; Stomatitis, Aphthous
Type
journal article