Metabolism of territrem A in liver microsomes from Wistar rats: 2. Sex differences and regulation with gonadal hormones and phenobarbital
Journal
Journal of Toxicology and Environmental Health - Part A
Journal Volume
64
Journal Issue
8
Pages
661-671
Date Issued
2001
Author(s)
Abstract
The aim of the present study was to assess the effects of sex difference on metabolism of territrem A (TRA) by liver microsomes from 7-wk-old Wistar rats. Metabolism of TRA to 2-dihydro-4β-demethylterritrem A (MA2) through 4,β-hydroxymethyl-4βdemethylterritrem A (MA1) and 4βoxo-4β-demethylterritrem A (MAX) was observed in intact male rats. However, in intact female rats only MA1 was formed, although the amount of MA1 formed in females was much less than in males. Phenobarbital pretreatment enhanced this step and was not affected by gonadectomy. In the gonadectomized rats of both sexes, MA2 was formed from TRA when the animals were further treated by testosterone and was significantly enhanced by treatment with phenobarbital. However, estradiol treatment or estradiol in combination with phenobarbital treatment did not affect MA2 formation from TRA in gonadectomized rats.
Type
journal article