https://scholars.lib.ntu.edu.tw/handle/123456789/292260
DC Field | Value | Language |
---|---|---|
dc.contributor.author | HAI-GWO HWU | en |
dc.contributor.author | CHIH-MIN LIU | en |
dc.creator | Liu, C.-M.;Hwu, H.-G.;Lin, M.-W.;Ou-Yang, W.-C.;Lee, S.F.-C.;Fann, C.S.J.;Wong, S.-H.;Hsieh, S.-H. | - |
dc.date.accessioned | 2018-09-10T03:44:17Z | - |
dc.date.available | 2018-09-10T03:44:17Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-0035829960&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/292260 | - |
dc.description.abstract | In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11-14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13-14 in an ethnically distinct Taiwanese sample. ? 2001 Wiley-Liss, Inc. | - |
dc.language | en | en |
dc.relation.ispartof | American Journal of Medical Genetics - Neuropsychiatric Genetics | en_US |
dc.source | AH | - |
dc.subject | Chromosome 15q; Linkage; Schizophrenia | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | microsatellite DNA; article; chromosome 15q; genetic linkage; genotype; human; major clinical study; marker gene; phenotype; priority journal; psychosis; schizoidism; schizophrenia; scoring system; Taiwan; Chromosomes, Human, Pair 15; DNA; Family; Family Health; Female; Genotype; Humans; Linkage (Genetics); Lod Score; Male; Microsatellite Repeats; Models, Genetic; Pedigree; Phenotype; Schizophrenia; Taiwan | - |
dc.title | Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/ajmg.1547 | - |
dc.relation.pages | 658-661 | - |
dc.relation.journalvolume | 105 | - |
dc.relation.journalissue | 8 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.orcid | 0000-0001-7016-8990 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系 |
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