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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/294917
Title: Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts
Authors: YUH JANG 
Keywords: Breast cancer; Docetaxel; Fluoropyrimidines; IL-6; Phosphorylase; Thymidine
Issue Date: 2001
Journal Volume: 48
Journal Issue: 4
Start page/Pages: 283-288
Source: Cancer Chemotherapy and Pharmacology 
Abstract: 
Purpose: Although several combination treatments with docetaxel and other antitumor agents have been tested in experimental and clinical studies, their synergistic effects are still ill-defined. The degree of synergism between docetaxel and two oral fluoropyrimidines, tegafur and 5′-deoxy-5-fluorouridine (5′-dFUrd), was investigated in the KPL-4 human breast cancer xenograft model. Methods: Because this KPL-4 cell line secretes interleukin-6 (IL-6) and induces cachexia, the effects of the combined treatment on serum IL-6 levels and cachectic markers were investigated. In addition, the expression levels of thymidine phosphorylase (dThdPase), a key enzyme for converting 5′-dFUrd to 5-fluorouracil, were determined. Female nude mice bearing KPL-4 tumors were treated orally with 5′-dFUrd (60 mg/kg, five times a week) or tegafur (100 mg/kg, five times a week) and by intraperitoneal injection of docetaxel (5 or 10 mg/kg, once a week). Results: Although docetaxel (5 mg/kg) alone did not decrease either tumor growth or serum IL-6 levels, docetaxel (5 mg/kg) plus 5′-dFUrd or tegafur enhanced tumor growth inhibition and decreased serum IL-6 levels more than 5′-dFUrd or tegafur alone. Docetaxel (5 mg/kg) alone slightly increased the percentage of dThdPase-positive tumor cells, but the combined treatment with docetaxel plus 5′-dFUrd or tegafur significantly decreased the percentage of dThdPase-positive cells in the KPL-4 tumors. Conclusion: These findings indicate that docetaxel may stimulate dThdPase expression in tumor tissues and may enhance the antitumor activity of oral fluoropyrimidines. In addition, combined treatment with docetaxel and oral fluoropyrimidines may decrease serum IL-6 levels and may ameliorate IL-6-induced cancer cachexia.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034852604&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/294917
DOI: 10.1007/s002800100325
Appears in Collections:職能治療學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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