https://scholars.lib.ntu.edu.tw/handle/123456789/297322
標題: | Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra | 作者: | Sheu, J.-H. Ahmed, A.F. Shiue, R.-T. CHANG-FENG DAI Kuo, Y.-H. |
公開日期: | 2002 | 卷: | 65 | 期: | 12 | 起(迄)頁: | 1904-1908 | 來源出版物: | Journal of Natural Products | 摘要: | Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-12244257495&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/297322 |
DOI: | 10.1021/np020280r | SDG/關鍵字: | dichloromethane; diterpenoid; norditerpenoid; scabrolide; unclassified drug; article; cancer cell; cell line; controlled study; coral; cytotoxicity; epimer; extract; human; human cell; isolation procedure; metabolite; nuclear Overhauser effect; structure analysis; Taiwan; Animals; Anthozoa; Diterpenes; Drug Screening Assays, Antitumor; Gas Chromatography-Mass Spectrometry; Humans; KB Cells; Methylene Chloride; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Sinularia |
顯示於: | 海洋研究所 |
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