https://scholars.lib.ntu.edu.tw/handle/123456789/297608
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KENG-CHEN LIANG | en |
dc.creator | Liang, KC and Melia, KR and Miserendino, MJ and Falls, WA and Campeau, S and Davis, M | - |
dc.date.accessioned | 2018-09-10T04:10:50Z | - |
dc.date.available | 2018-09-10T04:10:50Z | - |
dc.date.issued | 1992 | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/297608 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026633458&doi=10.1523%2fjneurosci.12-06-02303.1992&partnerID=40&md5=09b8786086f51a7bb07f0e8cef78a39c | - |
dc.description.abstract | Intracerebroventricular infusion of corticotropin-releasing factor (CRF) (0.1-1.0 μg) produced a pronounced, dose-dependent enhancement of the acoustic startle reflex in rats. This excitatory effect began about 20-30 min after infusion, grew steadily over the 2 hr test period, and lasted at least 6 hr. Higher doses of CRF (10 μg) often produced marked facilitation and then inhibition of startle that oscillated repeatedly with a period of 10-20 min. CRF-enhanced startle did not result from an increase in sensitization produced by repetition of the startle stimulus or from a blockade of habituation. Peripheral injections of the autonomic ganglionic blockers hexamethonium (10 mg/kg) or chlorisondamine (3 mg/kg) slightly attenuated the magnitude of CRF-enhanced startle, suggesting a partial role of peripheral sympathetic activation. Intracerebroventricular infusion of the CRF antagonist α-helical CRF9-41 (αhCRF; 25 or 50 μg) blocked CRF-enhanced startle when infused 5 min prior to CRF, indicating a central site of action. CRF-enhanced startle also was reversed when αhCRF was given 90 min after infusion of CRF. This suggests that exogenously applied CRF remains in the brain for a very long time after administration or that CRF given exogenously initiates a process that results in a long-lasting activation of endogenous CRF. Because the startle reflex is elevated by both conditioned and unconditioned fear, these data lend further support to the idea that CRF infusion produces a behavioral state that resembles fear or anxiety. Because startle is mediated by a well-defined neural pathway, CRF-enhanced startle may provide a useful behavioral assay to analyze the neural systems upon which exogenous CRF acts to produce its behavioral effects. | - |
dc.language | en | en |
dc.relation.ispartof | The Journal of neuroscience | en_US |
dc.source | AH | - |
dc.subject | chlorisondamine; corticotropin releasing factor; corticotropin releasing factor[9-41]; hexamethonium; animal experiment; animal tissue; anxiety; article; auditory stimulation; autonomic ganglion; behavior; controlled study; dose response; drug effect; facilitation; fear; hypothalamus; hypothalamus hypophysis system; intracerebroventricular drug administration; male; nonhuman; priority journal; protein analysis; protein determination; rat; startle reflex | - |
dc.title | Corticotropin-releasing factor: long-lasting facilitation of the acoustic startle reflex | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1523/jneurosci.12-06-02303.1992 | - |
dc.identifier.scopus | 2-s2.0-0026633458 | - |
dc.relation.pages | 2303-2312 | - |
dc.relation.journalvolume | 12 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.orcid | 0000-0002-3292-6882 | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 心理學系 |
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