https://scholars.lib.ntu.edu.tw/handle/123456789/300071
標題: | Hypoparathyroidism in transfusion-dependent patients with β-thalassemia | 作者: | KAI-HSIN LIN | 關鍵字: | Chelation; Hypocalcemia; Hypoparathyroidism; Iron overload; Thalassemia; Transfusion | 公開日期: | 2002 | 卷: | 24 | 期: | 4 | 起(迄)頁: | 291-293 | 來源出版物: | Journal of Pediatric Hematology/Oncology | 摘要: | Purpose: To determine the prevalence of hypoparathyroidism in transfusion-dependent patients with β-thalassemia. Patients and Methods: A total of 28 transfusion-dependent patients with β-thalassemia were interviewed, and their serum calcium, phosphate, magnesium, and intact parathyroid hormone levels were checked. Serum ferritin levels were measured to monitor the effect of chelation therapy. Blood urea nitrogen, creatinine, total protein, and albumin were measured in patients with undetectable or low intact parathyroid hormone levels. Results: The prevalence of hypoparathyroidism was 10.7% (3/28). Mean age at diagnosis was 18 years. The serum ferritin levels of patients with hypoparathyroidism were 1,032, 2,102, and 7,680 μg/L. Only one patient had clinical symptoms of hypocalcemia. All three of the patients with hypoparathyroidism had hypogonadism, and 66.7% (2/3) of the patients had insulin-dependent diabetes mellitus. Conclusions: Hypoparathyroidism in transfusion-dependent patients with β-thalassemia seems to be accompanied by other endocrinopathies. Serum ferritin may not have been a reliable indicator of iron overload in the three patients with hypoparathyroidism. Severe iron overload would easily explain these multiple endocrinopathies This pattern is commonly seen in iron-overloaded patients with thalassemia elsewhere. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0036245025&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/300071 |
DOI: | 10.1097/00043426-200205000-00014 | SDG/關鍵字: | calcium; creatinine; ferritin; magnesium; nitrogen; parathyroid hormone; phosphate; protein; serum albumin; urea; adolescent; adult; article; beta thalassemia; blood transfusion; calcium blood level; chelation therapy; child; clinical article; creatinine blood level; female; ferritin blood level; human; hypocalcemia; hypogonadism; hypoparathyroidism; insulin dependent diabetes mellitus; iron overload; magnesium blood level; male; parathyroid hormone blood level; phosphate blood level; prevalence; priority journal; protein blood level; urea nitrogen blood level; Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Calcium; Female; Ferritins; Hepatitis B; Hepatitis C; Humans; Hypoparathyroidism; Iron; Iron Overload; Magnesium; Male; Parathyroid Hormone; Phosphates; Taiwan |
顯示於: | 醫學系 |
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