https://scholars.lib.ntu.edu.tw/handle/123456789/303303
標題: | Neuronal Damage after Ischemic Injury in the Middle Cerebral Arterial Territory: Deep Watershed versus Territorial Infarction at MR Perfusion and Spectroscopic Imaging | 作者: | Liu, Y.-J. Chen, C.-Y. Chung, H.-W. Huang, I.-J. Lee, C.-S. Chin, S.-C. Liou, M. HSIAO-WEN CHUNG |
關鍵字: | Brain, infarction; Brain, MR; Magnetic resonance (MR), perfusion study | 公開日期: | 2003 | 卷: | 229 | 期: | 2 | 起(迄)頁: | 366-374 | 來源出版物: | Radiology | 摘要: | PURPOSE: To determine the temporal patterns of neuronal injury between infarction subtypes and their possible association with changes in cerebral blood volume (CBV). MATERIALS AND METHODS: Twenty-five patients with ischemic injuries of middle cerebral arterial territories and receiving only conservative treatments were classified into territorial infarction (TI) (n = 16) and watershed infarction (WI) (n = 9) groups and were prospectively evaluated with longitudinal magnetic resonance (MR) examinations. Each patient underwent as many as five MR studies at various stroke stages following stroke symptom onset. Dynamic susceptibility-weighted contrast material-enhanced MR imaging was performed to yield the relative CBV (rCBV). Chemical shift imaging was used to measure the relative levels of N-acetylaspartate (NAA) and lactate of the ischemic brain tissue. Repeated-measures analysis of variance was used to examine the statistical significance in evolutional differences between TI and WI. RESULTS: For patients with TI, rCBV followed a progressively increasing pattern, from initial low values (0.46 ± 0.28 [SD]) to peak high values (1.23 ± 0.34) at early chronic stage. Relative NAA level decreased to 0.40 ± 0.24 during acute stroke and was lost completely 4 days after ictus. Patients with WI showed consistently high rCBV throughout all stages, with residual relative NAA level (0.53 ± 0.25) even at 1 month after symptom onset. Relative lactate level of patients with TI was significantly higher than that of patients with WI at the acute stage (P < .01). Differences in the temporal changes of both rCBV and brain metabolites between TI and WI were significant (P < .01). CONCLUSION: The different temporal patterns for stroke progression in TI and WI are associated with different evolutions of hemodynamics and neuronal injury. ? RSNA, 2003. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0142148009&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/303303 |
DOI: | 10.1148/radiol.2292020639 | SDG/關鍵字: | n acetylaspartic acid; adult; aged; article; brain ischemia; clinical article; disease course; female; human; image processing; male; middle cerebral artery; nerve cell lesion; nuclear magnetic resonance imaging; priority journal; Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Contrast Media; Diagnosis, Differential; Disease Progression; Female; Humans; Infarction, Middle Cerebral Artery; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Time Factors |
顯示於: | 生醫電子與資訊學研究所 |
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