https://scholars.lib.ntu.edu.tw/handle/123456789/303717
標題: | Activation of Protooncogene C-jun by the X Protein of Hepatitis B Virus | 作者: | Twu, J S Lai, M Y DING-SHINN CHEN Robinson, W S |
公開日期: | 1993 | 卷: | 192 | 期: | 1 | 起(迄)頁: | 346-350 | 來源出版物: | Virology | 摘要: | A specific viral oncogenic mechanism has not been shown for hepatitis B virus (HBV), although persistent HBV infection has been strongly associated with the development of hepatocellular carcinoma (HCC). Most HCCs in HBV carriers contain integrated viral sequences in host DNA and this raises the question of whether such integrations ever contribute to oncogenesis. HBV does contain a gene (designated the hbx gene) which encodes a transcriptional trans-activator protein capable of activating homologous and heterologous regulatory sequences. Hbx has been detected in some human HCC with HBV integrations and the expressed hbx protein appears to have transcriptional transactivating activity. These findings raise the possibility that hbx expression could contribute to hepatocarcinogenesis by activating cellular genes that could contribute to oncogenicity. The possibility that the hbx protein may activate certain protooncogenes was investigated and we found that hbx can activate the protooncogene c-jun promoter. c-Jun was found to be expressed at a very low level in normal liver tissue but at high levels in HCCs of HBV-infected patients. ? 1993 Academic Press. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027317952&doi=10.1006%2fviro.1993.1041&partnerID=40&md5=8a26913ae6c4d339d3079ed399a1a06f http://scholars.lib.ntu.edu.tw/handle/123456789/303717 |
DOI: | 10.1006/viro.1993.1041 | SDG/關鍵字: | article; carcinogenesis; gene activation; hepatitis b virus; liver cell carcinoma; nonhuman; priority journal; proto oncogene; Base Sequence; Carcinoma, Hepatocellular; Gene Expression Regulation; Genes, jun; Hepatitis B; Human; Liver Neoplasms; Molecular Sequence Data; Oligodeoxyribonucleotides; Promoter Regions (Genetics); Proto-Oncogene Proteins c-jun; RNA, Messenger; Trans-Activation (Genetics); Trans-Activators |
顯示於: | 醫學系 |
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