https://scholars.lib.ntu.edu.tw/handle/123456789/306919
標題: | Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca 2+-Triggered Exocytosis | 作者: | Han, Xue CHIH-TIEN WANG Bai, Jihong Chapman, Edwin R. Jackson, Meyer B. |
公開日期: | 四月-2004 | 卷: | 304 | 期: | 5668 | 起(迄)頁: | 289 - 292 | 來源出版物: | Science | 摘要: | The fusion pore of regulated exocytosis is a channel that connects and spans the vesicle and plasma membranes. The molecular composition of this important intermediate structure of exocytosis is unknown. Here, we found that mutations of some residues within the transmembrane segment of syntaxin (Syx), a plasma membrane protein essential for exocytosis, altered neurotransmitter flux through fusion pores and altered pore conductance. The residues that influenced fusion-pore flux lay along one face of an α-helical model. Thus, the fusion pore is formed at least in part by a circular arrangement of 5 to 8 Syx transmembrane segments in the plasma membrane. |
URI: | http://europepmc.org/abstract/med/15016962 http://scholars.lib.ntu.edu.tw/handle/123456789/306919 https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842429864&doi=10.1126%2fscience.1095801&partnerID=40&md5=d6ed91949da7668eb86ec0e488a77792 |
ISSN: | 00368075 | DOI: | 10.1126/science.1095801 |
顯示於: | 分子與細胞生物學研究所 |
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