https://scholars.lib.ntu.edu.tw/handle/123456789/307082
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 骨科 | en |
dc.contributor.author | Hsu, S.-H. | en_US |
dc.contributor.author | Chu, W.-P. | en_US |
dc.contributor.author | Lin, Y.-S. | en_US |
dc.contributor.author | Chiang, Y.-L. | en_US |
dc.contributor.author | Chen, D.C. | en_US |
dc.contributor.author | Tsai, C.-L. | en_US |
dc.contributor.author | SHAN-HUI HSU | zz |
dc.contributor.author | 江郁霖 | zz |
dc.contributor.author | 陳震漢 | zz |
dc.contributor.author | 蔡清霖 | zz |
dc.creator | 蔡清霖;陳震漢;江郁霖;SHAN-HUI HSU;Tsai, C.-L.;Chen, D.C.;Chiang, Y.-L.;Lin, Y.-S.;Chu, W.-P.;Hsu, S.-H.;SHAN-HUI HSU | - |
dc.date.accessioned | 2018-09-10T04:47:26Z | - |
dc.date.available | 2018-09-10T04:47:26Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-3042519184&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/307082 | - |
dc.description.abstract | The effect of a recombinant RGD (arginine-glycine-aspartic acid)- containing fusion protein, cellulose-binding domain ( CBD)RGD, on the cellular adhesion to a biomedical polyurethane (PU) was evaluated. A series of different cell lines, as well as freshly harvested animal cells, were grown on the PU surfaces with or without CBD-RGD, in serum or serum- free media. The results showed that the enhancement of cellular attachment by CBD-RGD varied with cell types. This is believed to be a result of the unique integrin receptors on each type of cell surface. The existence of certain divalent ions (Mg2+ and Mn2+) may increase the efficacy of the CBD -RGD, in a cell type-dependent manner. The fusion protein was also found to inhibit the platelet activation. The effect of CBD-RGD was further examined in two other substrate materials, poly(L-lactide) (PLLA) and poly (lactide -co-glycolide) (PLGA). The effect on cellular adhesion correlated with the amount of CBD-RGD physically adsorbed on the material surface. ( C) 2004 Elsevier B.V. All rights reserved. | en |
dc.language | en | en |
dc.relation.ispartof | Journal of Biotechnology | en_US |
dc.source | AH | - |
dc.subject | RGD-containing peptides | en |
dc.subject | polyurethane | en |
dc.subject | poly(L-lactide) | en |
dc.subject | poly( lactide-co-glycolide) | en |
dc.title | The effect of an RGD-containing fusion protein CBD-RGD in promoting cellular adhesion | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jbiotec.2004.03.014 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
dc.relation.pages | 143-154 | - |
dc.relation.journalvolume | 111 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
顯示於: | 高分子科學與工程學研究所 |
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