https://scholars.lib.ntu.edu.tw/handle/123456789/307992
標題: | New β-Caryophyllene-Derived Terpenoids from the Soft Coral Sinularia nanolobata | 作者: | Ahmed, Atallah F. CHANG-FENG DAI Su, Jui-Hsin Shiue, Ru-Ting Pan, Xin-Jie Dai, Chang-Feng Kuo, Yao-Haur Sheu, Jyh-Horng |
公開日期: | 2004 | 卷: | 67 | 期: | 4 | 起(迄)頁: | 592-597 | 來源出版物: | Journal of Natural Products | 摘要: | Two new norsesquiterpenoids, nanonorcaryophyllenes A (1) and B (2), two new diterpenoids, nanolobatins A (3) and B (4), and a novel norditerpenoid, nanolobatin C (5), were isolated from the n-hexane extract of the Taiwanese soft coral Sinularia nanolobata. Also, two new furanone derivatives, 6 and 7, were isolated for the first time from natural sources. The structures of 1-5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites. Nanonorcaryophyllenes A (1) and B (2) were characterized as 13-norcaryophyllenes that lack a methyl group at C-11, while nanolobatin C (5) represents the first example of a xeniaphyllane-based 17-norditerpenoid. The cytotoxicity of 1-6 against the growth of a limited panel of cancer cell lines is also described. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-2042423135&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/307992 |
DOI: | 10.1021/np030286w | SDG/關鍵字: | 13 norcaryophyllene derivative; 17 norditerpenoid derivative; caryophyllene; caryophyllene derivative; diterpenoid; doxorubicin; drug metabolite; furanone derivative; hexane; methyl group; nanolobatin A; nanolobatin B; nanolobatin C; nanonorcaryophyllene A; nanonorcaryophyllene B; sesquiterpenoid; terpenoid derivative; unclassified drug; antineoplastic activity; article; cancer cell culture; cancer inhibition; carbon nuclear magnetic resonance; cell assay; controlled study; coral; cytopathogenic effect; drug isolation; drug structure; high performance liquid chromatography; human; human cell; in vitro study; infrared spectroscopy; mass spectrometry; nonhuman; proton nuclear magnetic resonance; Sinularia nanolobata; stereochemistry; structure analysis; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Diterpenes; Drug Screening Assays, Antitumor; Humans; KB Cells; Molecular Structure; Oceans and Seas; Sesquiterpenes; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Sinularia |
顯示於: | 海洋研究所 |
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