|Title:||Association of GSTP1 polymorphism and survival for esophageal cancer||Authors:||SHUENN-WEN KUO
|Issue Date:||2005||Journal Volume:||11||Journal Issue:||13||Start page/Pages:||4749-4753||Source:||Clinical Cancer Research||Abstract:||
Purpose: Activity of glutathione S-transferase (GST) is associated with detoxification of xenobiotics and the maintenance of cell viability. Genetically variant GSTs produce different enzymatic activities. The clinical significance of this variation is still puzzling. We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients. Experimental Design: From 1996 to 2002,233 patients with pathologically proven esophageal cancer were recruited from the Department of Surgery, National Taiwan University Hospital. GST genotypes, including GSTT1, GSTM1, and GSTP1, were determined by PCR or PCR-RFLP. The influence of the genetic polymorphisms on patient survival was estimated using the method of Kaplan-Meier survival function and Cox proportional hazards models. Results: The mean survival times (months) of the GSTP1 Ile/Ile, Ile/Val, and Val/Val were 11,10, and 7, respectively (P < 0.05), The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.84; Ptrend=0.045). In contrast, no association of GSTT1 or GSTM1 genotypes with survival rate was noted. Conclusion: The presence of the GSTP1 variant allele (Val) is associated with a poorer prognosis of esophageal cancer. ? 2005 American Association for Cancer Research.
|DOI:||10.1158/1078-0432.CCR-04-2333||metadata.dc.subject.other:||antineoplastic agent; cisplatin; fluorouracil; glutathione transferase; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; isoleucine; paclitaxel; unclassified drug; valine; adult; aged; article; cancer adjuvant therapy; cancer radiotherapy; cancer surgery; cancer survival; cell viability; enzyme activity; esophagus cancer; female; gene; genetic polymorphism; genetic variability; genotype; GSTP1 gene; human; human tissue; Kaplan Meier method; major clinical study; male; nonbiological model; pathology; polymerase chain reaction; priority journal; prognosis; restriction fragment length polymorphism; survival time; xenobiotic metabolism; Adult; Aged; Aged, 80 and over; Alleles; Esophageal Neoplasms; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Polymorphism, Genetic; Survival Analysis
|Appears in Collections:||醫學系|
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