https://scholars.lib.ntu.edu.tw/handle/123456789/312984
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin T.-F. | en_US |
dc.contributor.author | YU-CHANG YEH | en_US |
dc.contributor.author | Yen Y.-H. | en_US |
dc.contributor.author | YONG-PING WANG | en_US |
dc.contributor.author | Lin C.-J. | en_US |
dc.contributor.author | WEI-ZEN SUN | en_US |
dc.creator | Lin, T.-F.;Yeh, Y.-C.;Yen, Y.-H.;Wang, Y.-P.;Lin, C.-J.;Sun, W.-Z. | - |
dc.date.accessioned | 2018-09-10T05:12:57Z | - |
dc.date.available | 2018-09-10T05:12:57Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-19944365226&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/312984 | - |
dc.description.abstract | Background. This study was designed to examine the analgesic and dose-related antiemetic efficacy of diphenhydramine-morphine mixture for intravenous patient-controlled analgesia (PCA). Methods. Healthy women, undergoing abdominal total hysterectomy were recruited to this double-blinded randomized placebo-controlled study. Patients were randomly allocated to one of three groups (n=40 each). In group 1, patients received saline at induction and morphine 1 mg ml-1 alone for postoperative PCA. Patients in groups 2 and 3 received diphenhydramine 30 mg i.v. at induction and were given a 1.2:1 or a 4.8:1 ratio, respectively, of diphenhydramine-morphine mixture for postoperative PCA. Results. A total of 112 patients completed the study. The incidence of postoperative nausea (31.6% vs 67.6%, P<0.01) and vomiting (15.8% vs 40.5%, <0.05) was significantly lower in group 3 than in group 1. Furthermore, the incidence of severe nausea was significantly lower in group 3 than in group 1 (2.6% vs 24.3%, P<0.05). The rescue antiemetic requirements were also significantly less in group 3 than in group 1 (5.3% vs 24.3%, P<0.05). However, there was no significant difference between group 2 and group 1 in any of the comparisons. Pain intensity, 24-h morphine consumption and diphenhydramine-related side-effects, such as sedation or dry mouth, did not differ among the three groups. Conclusion. An initial bolus of diphenhydramine 30 mg at anaesthetic induction followed by postoperative PCA with a 4.8:1, but not 1.2:1, diphenhydramine-morphine mixture provides an effective antiemetic efficacy without morphine-sparing effects. ? The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. | en_US |
dc.language | en | en |
dc.relation.ispartof | British Journal of Anaesthesia | en_US |
dc.source | AH | - |
dc.subject | Analgesia, patient-controlled; Antiemetic, diphenhydramine; Complications postoperative nausea and vomiting | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | diphenhydramine; morphine; placebo; prochlorperazine; sodium chloride; abdominal hysterectomy; add on therapy; adult; aged; analgesic activity; antiemetic activity; article; bolus injection; clinical trial; controlled clinical trial; controlled study; disease severity; double blind procedure; drug efficacy; female; human; incidence; major clinical study; patient controlled analgesia; postoperative analgesia; postoperative nausea and vomiting; postoperative pain; priority journal; randomized controlled trial; sedation; somnolence; statistical analysis; xerostomia | - |
dc.title | Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/bja/aei137 | - |
dc.relation.pages | 835-839 | en_US |
dc.relation.journalvolume | 94 | en_US |
dc.relation.journalissue | 6 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.orcid | 0000-0001-5143-5520 | - |
crisitem.author.orcid | 0000-0002-5111-1443 | - |
crisitem.author.orcid | 0000-0001-8543-2600 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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