https://scholars.lib.ntu.edu.tw/handle/123456789/313461
標題: | Neutralizing antibody response and SARS severity. | 作者: | Ho, Mei-Shang Chen, Wei-Ju Chen, Hour-Young Lin, Szu-Fong Wang, Min-Chin Di, Jiali Lu, Yen-Ta Liu, Ching-Lung SHAN-CHWEN CHANG Chao, Chung-Liang King, Chwan-Chuen Chiou, Jeng-Min Su, Ih-Jen Yang, Jyh-Yuan |
公開日期: | 十一月-2005 | 來源出版物: | Emerging Infectious Diseases | 摘要: | Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks. Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). When early responders were compared with most patients, who seroconverted on and after week 3 of illness, the small proportion (17.4%) of early responders (antibody detectable within 2 weeks) had a higher death rate (29.6% vs. 7.8%) (Fisher exact test, p = 0.004), had a shorter survival time of <2 weeks (Fisher exact test, p = 0.013), and were more likely to be > 60 years of age (Fisher exact test, p = 0.01). Our findings have implications for understanding the pathogenesis of SARS and for SARS vaccine research and development. |
URI: | http://europepmc.org/abstract/med/16318725 http://scholars.lib.ntu.edu.tw/handle/123456789/313461 |
DOI: | 10.3201/eid1111.040659 | SDG/關鍵字: | neutralizing antibody; severe acute respiratory syndrome vaccine; unclassified drug; virus vaccine; adult; antibody response; antibody titer; article; data analysis; disease severity; female; half life time; high risk patient; human; major clinical study; male; reverse transcription polymerase chain reaction; SARS coronavirus; seroconversion; severe acute respiratory syndrome; survival time; Taiwan; vaccine production; virus detection |
顯示於: | 醫學系 |
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