https://scholars.lib.ntu.edu.tw/handle/123456789/313789
Title: | A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus | Authors: | FUN-IN WANG | Keywords: | brain expression; carcinoembryonic antigen; coronavirus; virus receptor | Issue Date: | 1995 | Journal Volume: | 92 | Journal Issue: | 26 | Start page/Pages: | 12095-12099 | Source: | Proceedings of the National Academy of Sciences of the United States of America | Abstract: | Mouse hepatitis virus (MHV), a murine coronavirus known to cause encephalitis and demyelination, uses murine homologues of carcinoembryonic antigens as receptors. However, the expression of these receptors is extremely low in the brain. By low-stringency screening of a mouse brain cDNA library, we have identified a member of the pregnancy-specific glycoprotein (PSG) subgroup of the carcinoembryonic antigen gene family. Unlike other PSG that are expressed in the placenta, it is expressed predominantly in the brain. Transfection of the cDNA into COS-7 cells, which lack a functional MHV receptor, conferred susceptibility to infection by some MHV strains, including A59, MHV-2, and MHV-3, but not JHM. Thus, this is a virus strain- specific receptor. The detection of multiple receptors for MHV suggests the flexibility of this virus in receptor utilization. The identification of a PSG predominantly expressed in the brain also expands the potential functions of these molecules. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0029608722&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/313789 |
DOI: | 10.1073/pnas.92.26.12095 | SDG/Keyword: | brain protein; carcinoembryonic antigen; complementary dna; glycoprotein; virus receptor; animal cell; antigen specificity; article; female; gene expression regulation; mouse; murine hepatitis coronavirus; nonhuman; pregnancy; priority journal; protein determination; receptor binding; receptor occupancy; sequence homology; strain difference; Amino Acid Sequence; Animals; Base Sequence; Brain; Carcinoembryonic Antigen; Cell Line; Cercopithecus aethiops; Female; Gene Library; Kidney; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Murine hepatitis virus; Organ Specificity; Placenta; Polymerase Chain Reaction; Pregnancy; Pregnancy Proteins; Receptors, Virus; Sequence Homology, Amino Acid; Transfection; Animalia; Coronavirus; Hepatitis virus A; Murinae; Murine hepatitis virus |
Appears in Collections: | 分子暨比較病理生物學研究所 |
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