https://scholars.lib.ntu.edu.tw/handle/123456789/32035
標題: | 雙光子顯微術觀測分子電荷在離子導入術下對皮膚穿透之影響 Charge Dependence on the Transdermal Iontophoretic Delivery Revealed by Multiphoton Microscopic Imaging |
作者: | 陳潔 Chen, Jie |
關鍵字: | 雙光子顯微術;離子導入術;皮膚;multiphoton microscopy;iontophoresis;transdermal delivery | 公開日期: | 2005 | 摘要: | 在本篇文章裡,我們利用雙光子顯微術為工具,研究一種經過皮膚吸收藥物系統的促進方法--離子導入術。在這個課題裡,我們又選擇其中的一個子題,亦即,在改變被傳遞的藥物於中性生理環境所攜帶的電荷數這個變因下,我們希望能觀察到,對離子導入術的藥物傳遞增益效果會發生什麼影響。由於利用螢光顯微術視覺化的探討藥物傳遞的效果,我們得以針對藥物在皮膚組織裡的分布作不同於一般研究離子導入術的觀察。實驗結果證明了,藥物不同的電性對於傳遞的效益和傳遞的路徑會造成影響,並且是具有生物物理意義的一種效果。 In this thesis we utilize multiphoton microscope as a tool to investigate an enhancement method of transdermal delivery system, that is, iontophoresis. We choose the charge carried by fluorescent model drugs as a varient factor. We study the dependence of molecular charge in transdermal iontophoretic molecular delivery. We chose 6,8-dihydroxy-1,3-pyrenedisulfonic acid disodium salt, 8- hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt, and calcein with the respective charges of -2, -3, and -4. These molecules are used as model drugs to probe the difference in iontophoretic delivery pathways when using molecules with different charges. Because of the visualization ablilty of fluorescent microscopy, it becomes able for us to observe the distribution of model drug inside the skin tissue, which is different from the traditional ways used for this experiment. The result shows that the charge of the molecules can affect the delivery efficiency and the delivery path, and is of physical meaning. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/54556 | 其他識別: | zh-TW |
顯示於: | 物理學系 |
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ntu-94-R92222001-1.pdf | 23.53 kB | Adobe PDF | 檢視/開啟 |
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