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  3. National Taiwan University Hospital / 醫學院附設醫院 (臺大醫院)
  4. Oxidative stress during 1-lung ventilation
 
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Oxidative stress during 1-lung ventilation

Journal
Journal of Thoracic and Cardiovascular Surgery
Journal Volume
132
Journal Issue
3
Pages
513-518
Date Issued
2006
Author(s)
YA-JUNG CHENG  
KUANG-CHEGN CHAN  
Chien, Chiang-Ting
WEI-ZEN SUN  
Lin, Chen-Jung
DOI
10.1016/j.jtcvs.2006.03.060
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-33747787404&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/320410
Abstract
Objectives: Resuming 2-lung ventilation from 1-lung ventilation might induce a re-expansion and reoxygenation effect. The oxidative stress during 1-lung ventilation/2-lung ventilation has not been studied, although severe complications, such as re-expansion pulmonary edema, were reported. Reactive oxygen species production and total antioxidant status assay levels were measured in this study during 1-lung ventilation/2-lung ventilation. The effects on extravascular lung water, cardiac output, and intrathoracic blood volume were also studied by using the Pulsion PiCCO system. Methods: Twenty patients undergoing 1-lung ventilation/2-lung ventilation (>60 minutes) for video-assisted thoracoscopic surgery with minimal lung injuries were included in this study. Reactive oxygen species production was measured by means of lucigenin (detecting superoxide mainly) and luminol (detecting H2O2 and HOCl mainly) chemiluminescence. Reactive oxygen species production, total antioxidant status assay (by using the Randox TAS kit), extravascular lung water, cardiac output, and intrathoracic blood volume values were measured before 1-lung ventilation (T1), before resuming 2-lung ventilation (T2), 5 minutes after 2-lung ventilation (T3), and 30 minutes after 2-lung ventilation (T4). Results: One-lung ventilation time was 118 ± 33 minutes. Lucigenin chemiluminescence (but not luminol chemiluminescence) increased significantly at T3 and T4. Total antioxidant status decreased nonsignificantly. Extravascular lung water, intrathoracic blood volume, and permeability index values changed nonsignificantly after 2-lung ventilation. Cardiac output increased significantly at T4, and there is a negative correlation between cardiac output and extravascular lung water (r = -0.431, P < .005). Conclusions: Resuming 2-lung ventilation induces a massive superoxide production. Comparable extravascular lung water and intrathoracic blood volume and a nonsignificant decrease of total antioxidant status indicate adequate antioxidant capacity to counteract it. Severe oxidative injuries after 1-lung ventilation/2-lung ventilation should be considered in patients without adequate antioxidative capacity, such as those with cancer and trauma. ? 2006 The American Association for Thoracic Surgery.
SDGs

[SDGs]SDG3

Other Subjects
antioxidant; hydrogen peroxide; lucigenin; luminol; reactive oxygen metabolite; superoxide; adult; article; assay; blood volume; chemoluminescence; clinical article; correlation analysis; endoscopic surgery; heart output; human; lung extravascular fluid; lung fluid; lung injury; lung ventilation; oxidative stress; priority journal; Adult; Antioxidants; Female; Humans; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Respiration, Artificial; Thoracic Surgery, Video-Assisted
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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