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  4. Test of equivalence and non-inferiority for diagnostic accuracy based on the paired areas under ROC curves
 
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Test of equivalence and non-inferiority for diagnostic accuracy based on the paired areas under ROC curves

Journal
Statistics in Medicine
Journal Volume
25
Journal Issue
7
Pages
1219-1238
Date Issued
2006
Author(s)
JEN-PEI LIU  
Ma, M.-C.
Wu, C.-Y.
Tai, J.-Y.
DOI
10.1002/sim.2358
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-33645469682&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/322163
Abstract
Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-sided tests (TOST) based on the difference in paired areas under ROC curves estimated by the non-parametric method. We propose to use the standardized difference for assessing equivalence or non-inferiority in diagnostic accuracy based on paired areas under ROC curves between two diagnostic procedures. The bootstrap technique is also suggested for both non-parametric method and the standardized difference approach. A simulation study was conducted empirically to investigate the size and power of the four methods for various combinations of distributions, data types, sample sizes, and different correlations. Simulation results demonstrate that the bootstrap procedure of the standardized difference approach not only can adequately control the type I error rate at the nominal level but also provides equivalent power under both symmetrical and skewed distributions. A numerical example using published data illustrates the proposed methods. Copyright ? 2005 John Wiley & Sons, Ltd.
Subjects
Non-parametric method; Paired areas under ROC curves; Standardized difference; Two one-sided tests
SDGs

[SDGs]SDG3

Other Subjects
analytical error; article; atherosclerosis; clinical article; diagnostic accuracy; diagnostic procedure; digital subtraction angiography; human; hypothesis; methodology; nonparametric test; nuclear magnetic resonance imaging; power analysis; probability; receiver operating characteristic; sample size; standard; statistical analysis; statistical distribution; three dimensional imaging; clinical trial; comparative study; computer simulation; controlled clinical trial; pharmacokinetics; preventive health service; randomized controlled trial; roc curve; sensitivity and specificity; statistical model; statistics; Computer Simulation; Data Interpretation, Statistical; Diagnostic Services; Humans; Models, Statistical; Randomized Controlled Trials; Research Design; ROC Curve; Sample Size; Sensitivity and Specificity; Statistics, Nonparametric; Therapeutic Equivalency
Type
journal article

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