Evaluating microcirculation by pulsatile laser Doppler signal
Resource
INSTITUTE OF PHYSICS PUBLISHING PHYSICS IN MEDICINE & BIOLOGY Phys. Med. Biol. 51, 845–854
Journal
INSTITUTE OF PHYSICS PUBLISHING PHYSICS IN MEDICINE & BIOLOGY Phys. Med. Biol. 51, 845–854
Pages
-
Date Issued
2006
Date
2006
Author(s)
Chao, P.T.
Jan, M.Y.
Hsiu, H.
Hsu, T.L.
Wang, W.K.
Lin, Y.Y.
DOI
246246/2006111501211817
Abstract
Laser Doppler flowmetry (LDF) is a popular method for monitoring the microcirculation, but it does not provide absolute measurements. Instead, the mean flux response or energy distribution in the frequency domain is generally compared before & after stimulus. Using the heartbeat as a trigger, we investigated whether the relation between pressure & flux can be used to discriminate different microcirculatory conditions. We propose the following three pulsatile indices for evaluating the microcirculation condition from the normalized pressure & flux segment with a synchronized-averaging method: peak delay time (PDT), pressure rise time & flux rise time (FRT). The abdominal aortic blood pressure & renal cortex flux (RCF) signals were measured in spontaneously hypertensive rats (SHR) & Wistar Kyoto rats (WKY). The mean value of the RCF did not differ between SHR & WKY. However, the PDT was longer in SHR (87.14 ± 5.54 ms, mean ± SD) than in WKY (76.92 ± 2.62 ms; p < 0.001). The FRT was also longer in SHR (66.56 ± 1.98 ms) than in WKY (58.02 ± 1.77 ms; p < 0.001). We propose that a new dimension for comparing the LDF signals, which the results from the present study show, can be used to discriminate RCF signals that cannot be discriminated using traditional methods.
Publisher
Taipei:National Taiwan University Dept Phys
Type
journal article
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