A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice
Resource
Journal of Agricultural and Food Chemistry 55 (26): 11101-11108
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
55
Journal Issue
26
Pages
11101-11108
Date Issued
2007
Author(s)
Abstract
Monascus species-fermented red mold rice (RMR) has been regarded as a popular hypolipidemic functional food because it contains monacolin K, an inhibitor of de novo cholesterol synthesis. However, the safety of RMR is always an issue because citrinin is present in RMR and is reported to be hepatotoxic and nephrotoxic. The present study was therefore to develop a postprocess to remove citrinin yet retain monacoln K in the RMR preparation. We found that phosphate-ethanol extraction was effective for the removal citrinin, yet it could retain monacolin K, because the former was more hydrophilic than the latter in phosphate-ethanol solution. Ethanol, phosphate, and extraction time were optimized as factors of response surface methodology (RSM). It was found that the optimal RSM condition was 45% ethanol, 1.5% phosphate, and extraction for 70 min. Under this optimal condition, 91.6% citrinin was removed and 79.5% monacolin K was retained in the final RMR. © 2007 American Chemical Society.
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
55.pdf
Size
1.29 MB
Format
Adobe PDF
Checksum
(MD5):bd1e8e575c57353c7b8ddecfc6d31814