https://scholars.lib.ntu.edu.tw/handle/123456789/329677
Title: | Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations | Authors: | Lin, M.-W. Sham, P. HAI-GWO HWU Collier, David Murray, Robin Powell, John F. |
Issue Date: | 1997 | Journal Volume: | 99 | Journal Issue: | 3 | Start page/Pages: | 417-420 | Source: | Human Genetics | Abstract: | Previously we reported suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. We have now studied an additional independent sample of 44 pedigrees consisting of 34 Taiwanese, 9 English and 1 Welsh family in an attempt to replicate this finding. Narrow and broad models based on Research Diagnostic Criteria or the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised, were used to define the schizophrenia phenotype. Under a dominant genetic model, two-point 1od scores obtained for most of the markers were negative except that marker D13S122 gave a total 1od score of 1.06 (θ = 0.2, broad model). As combining pedigrees from different ethnic origins may be inappropriate, we combined this replication sample and our original sample, and then divided the total sample into Caucasian (English and Welsh pedigrees) and Oriental (Taiwanese and Japanese pedigrees) groups. The Caucasian pedigrees produced maximized admixture two-point lod scores (A-1od) of 1.41 for the marker D13S119 (θ = 0.2, α = 1.0) and 1.54 for D13S128 (θ = 0, α = 0.3) with nearby markers also producing positive A-led scores. When five-point model-free linkage analysis was applied to the Caucasian sample, a maximum 1od score of 2.58 was obtained around the markers D13S122 and D13S128, which are located on chromosome 13q32. The linkage results for the Oriental group were less positive than the Caucasian group. Our results again suggest that there is a potential susceptibility locus for schizophrenia on chromosome 13q14.1-q32, especially in the Caucasian population. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0031058747&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/329677 |
DOI: | 10.1007/s004390050382 | SDG/Keyword: | article; caucasian; chromosome 13q; disease predisposition; genetic linkage; genetic model; human; japan; pedigree; phenotype; priority journal; race difference; schizophrenia; taiwan; Asian Continental Ancestry Group; Chromosomes, Human, Pair 13; England; European Continental Ancestry Group; Humans; Linkage (Genetics); Lod Score; Microsatellite Repeats; Schizophrenia; Taiwan; Wales |
Appears in Collections: | 醫學系 |
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