Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Antibiotic resistance patterns of community-acquired urinary tract infections in children with vesicoureteral reflux receiving prophylactic antibiotic therapy
 
  • Details

Antibiotic resistance patterns of community-acquired urinary tract infections in children with vesicoureteral reflux receiving prophylactic antibiotic therapy

Journal
Pediatrics
Journal Volume
122
Journal Issue
6
Pages
1212-1217
Date Issued
2008
Author(s)
YONG-KWEI TSAU  
CHENG, CHI-HUI
TSAI, MING-HONG
HUANG, YHU-CHERING
SU, LIN-HUI
TSAU, YONG-KWEI
LIN, GHI-JEN
CHIU, CHENG-HSUN
LIN, TZOU- YIEN
DOI
10.1542/peds.2007-2926
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-58249094734&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/336195
Abstract
OBJECTIVE. The goal was to examine bacterial antimicrobial resistance of recurrent urinary tract infections in children receiving antibiotic prophylaxis because of primary vesicoureteral reflux. METHODS. We reviewed data retrospectively for children with documented vesicoureteral reflux in 2 hospitals during a 5-year follow-up period. The patients were receiving co-trimoxazole, cephalexin, or cefaclor prophylaxis or prophylaxis with a sequence of different antibiotics (alternative monotherapy). Demographic data, degree of vesicoureteral reflux, prophylactic antibiotics prescribed, and antibiotic sensitivity results of first urinary tract infections and breakthrough urinary tract infections were recorded. RESULTS. Three hundred twenty-four patients underwent antibiotic prophylaxis (109 with co-trimoxazole, 100 with cephalexin, 44 with cefaclor, and 71 with alternative monotherapy) in one hospital and 96 children underwent co-trimoxazole prophylaxis in the other hospital. Breakthrough urinary tract infections occurred in patients from both hospitals (20.4% and 25%, respectively). Escherichia coli infection was significantly less common in children receiving antibiotic prophylaxis, compared with their initial episodes of urinary tract infection, at both hospitals. Children receiving cephalosporin prophylaxis were more likely to have an extended-spectrum /3-lactamase-producing organism for breakthrough urinary tract infections, compared with children with co-trimoxazole prophylaxis. Antimicrobial susceptibilities to almost all antibiotics decreased with cephalosporin prophylaxis when recurrent urinary tract infections developed. The extent of decreased susceptibilities was also severe for prophylaxis with a sequence of different antibiotics. However, antimicrobial susceptibilities decreased minimally in co-trimoxazole prophylaxis groups. CONCLUSIONS. Children receiving cephalosporin prophylaxis are more likely to have extended-spectrum /3-lactamase-producing bacteria or multidrug-resistant uropathogens other than E coli for breakthrough urinary tract infections; therefore, these antibiotics are not appropriate for prophylactic use in patients with vesicoureteral reflux. Co-trimoxazole remains the preferred prophylactic agent for vesicoureteral reflux. Copyright ? 2008 by the American Academy of Pediatrics.
Subjects
Antibiotic resistance; Extended-spectrum β-lactamase; Prophylactic antibiotics; Recurrent urinary tract infection; Vesicoureteral reflux
SDGs

[SDGs]SDG3

Other Subjects
beta lactamase; cefaclor; cefalexin; cotrimoxazole; antiinfective agent; urinary tract antiinfective agent; antibiotic prophylaxis; antibiotic resistance; antibiotic sensitivity; article; child; Enterobacter cloacae; Enterococcus faecalis; Escherichia coli; female; follow up; human; infant; Klebsiella; major clinical study; male; Morganella morganii; preschool child; priority journal; Proteus; Pseudomonas aeruginosa; retrospective study; school child; urinary tract infection; vesicoureteral reflux; adolescent; age distribution; cohort analysis; communicable disease; confidence interval; hospitalization; incidence; microbiological examination; microbiology; newborn; probability; risk assessment; sex ratio; statistics; urinary tract infection; vesicoureteral reflux; Adolescent; Age Distribution; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antibiotic Prophylaxis; Child; Child, Preschool; Cohort Studies; Community-Acquired Infections; Confidence Intervals; Drug Resistance, Microbial; Female; Follow-Up Studies; Humans; Incidence; Infant; Infant, Newborn; Male; Microbial Sensitivity Tests; Probability; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Distribution; Urinary Tract Infections; Vesico-Ureteral Reflux
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science