https://scholars.lib.ntu.edu.tw/handle/123456789/337681
標題: | Movement-related cortical potentials in patients with Machado-Joseph disease | 作者: | Lu, M.-K. FANG-CHIA CHANG et al. |
關鍵字: | Bereitschaftspotential; Cerebello-thalamo-cortical circuit; Machado-Joseph disease (spinocerebellar ataxia type 3); Movement-related cortical potential; Offset cortical potential; Post-movement cortical potential | 公開日期: | 2008 | 卷: | 119 | 期: | 5 | 起(迄)頁: | 1010-1019 | 來源出版物: | Clinical Neurophysiology | 摘要: | Objective: Movement-related cortical potentials (MRCP; nomenclature of MRCP components according to Shibasaki and Hallett (Shibasaki H, Hallett M. What is the Bereitschaftspotential? Clin Neurophysiol 2006;117:2341-56) were studied in patients with Machado-Joseph disease (MJD) to elucidate the pathophysiology of voluntary movement. Methods: We studied nine genetically proven MJD patients and eight age-matched healthy subjects. Multi-channel electroencephalogram (EEG) recordings were obtained during self-paced fast extensions of the wrist. EEG epochs were time-locked to electromyography (EMG) onset or offset of the voluntary EMG burst and averaged. Results: In the MJD patients, the early Bereitschaftspotential (early BP, -1500 to -500 ms) was not affected but the late BP was reduced over the central midline area and contralaterally to the movement side. The amplitude of the fpMP, a post-movement MRCP component, was also reduced. In addition, the offset cortical potential in the first 500 ms after EMG offset (Moff + 500) was attenuated bilaterally over a wide cortical area. Conclusions: Findings suggest that cortical activations associated with the initiation and termination of a voluntary movement are impaired in MJD patients. Significance: Abnormalities of pre- and post-movement MRCP components provide researchers with pathophysiological insight into voluntary motor dysfunction in MJD. ? 2008 International Federation of Clinical Neurophysiology. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-41449083857&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/337681 |
DOI: | 10.1016/j.clinph.2008.01.008 | SDG/關鍵字: | adult; article; clinical article; contingent negative variation; controlled study; electroencephalogram; electromyography; evoked muscle response; female; human; Machado Joseph disease; male; motor dysfunction; motor performance; pathophysiology; priority journal; voluntary movement; wrist; Adult; Cerebral Cortex; Electroencephalography; Electromyography; Evoked Potentials, Motor; Female; Humans; Machado-Joseph Disease; Male; Motor Activity |
顯示於: | 獸醫學系 |
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