https://scholars.lib.ntu.edu.tw/handle/123456789/338489
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MIN-HSIUNG PAN | en_US |
dc.contributor.author | Hsieh, M.-C. | en_US |
dc.contributor.author | Kuo, J.-M. | en_US |
dc.contributor.author | Lai, C.-S. | en_US |
dc.contributor.author | Wu, H. | en_US |
dc.contributor.author | Sang, S. | en_US |
dc.contributor.author | Ho, C.-T. | en_US |
dc.creator | Pan, M.-H.;Hsieh, M.-C.;Kuo, J.-M.;Lai, C.-S.;Wu, H.;Sang, S.;Ho, C.-T. | - |
dc.date.accessioned | 2018-09-10T06:56:36Z | - |
dc.date.available | 2018-09-10T06:56:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-48649093632&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/338489 | - |
dc.description.abstract | Ginger, the rhizome of Zingiber officinale, is a traditional medicine with anti-inflammatory and anticarcinogenic properties. This study examined the growth inhibitory effects of the structurally related compounds 6-gingerol and 6-shogaol on human cancer cells. 6-Shogaol [1-(4-hydroxy-3-methoxyphenyl)-4- decen-3-one] inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of 6-shogaol-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. Up-regulation of Bax, Fas, and FasL, as well as down-regulation of Bcl-2 and Bcl-XL were observed in 6-shogaol-treated COLO 205 cells. N-acetylcysteine (NAC), but not by other antioxidants, suppress 6-shogaol-induced apoptosis. The growth arrest and DNA damage (GADD)-inducible transcription factor 153 (GADD153) mRNA and protein is markedly induced in a time- and concentration-dependent manner in response to 6-shogaol. ? 2008 Wiley-VCH Verlag GmbH & Co. KGaA. | - |
dc.language | en | en |
dc.relation.ispartof | Molecular Nutrition and Food Research | - |
dc.source | AH | - |
dc.subject | 6-Shogaol; Apoptosis; GADD153; Reactive oxygen species | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Zingiber officinale; caspase; catechol derivative; DDIT3 protein, human; fatty alcohol; gingerol; growth arrest and DNA damage inducible protein 153; plant extract; reactive oxygen metabolite; RNA; shogaol; adenocarcinoma; apoptosis; article; cell membrane potential; chemistry; colon tumor; colorectal tumor; drug effect; genetics; ginger; human; isolation and purification; metabolism; mitochondrial membrane; pathology; physiology; reverse transcription polymerase chain reaction; tumor cell line; Adenocarcinoma; Apoptosis; Caspases; Catechols; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Fatty Alcohols; Ginger; Humans; Membrane Potentials; Mitochondrial Membranes; Plant Extracts; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Transcription Factor CHOP | - |
dc.title | 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/mnfr.200700157 | - |
dc.relation.pages | 527-537 | - |
dc.relation.journalvolume | 52 | - |
dc.relation.journalissue | 5 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Food Science and Technology | - |
crisitem.author.orcid | 0000-0002-5188-7030 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 食品科技研究所 |
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