|Title:||Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B||Authors:||Huang, Tsui-Chin
|Issue Date:||Apr-2008||Journal Volume:||7||Journal Issue:||4||Start page/Pages:||1433–1444||Source:||Journal of Proteome Research||Abstract:||
Targeting of tumor tissues is one of the most powerful approaches to accelerate the efficiency of anticancer treatments. The investigation of effective targets, including proteins specifically and abundantly expressed in abnormal regions, has been one of the most important research topics in cancer therapy. In this study, we performed a proteomic analysis on human breast carcinoma tissues to investigate the tumor-specific protein expression in breast carcinoma. Our study showed that ATP synthase was up-regulated in tumor tissues and was present on the plasma membrane of breast cancer cells. Furthermore, we treated the breast cancer cells with ATP synthase inhibitors and examined the inhibitory efficiency. Aurovertin B, an ATP synthase inhibitor, has strong inhibition on the proliferation of several breast cancer cell lines, but little influence on the normal cell line MCF-10A. Aurovertin B inhibits proliferation of breast cancer cells by inducing apoptosis and arresting cell cycle at the G0/G1 phase. This study showed aurovertin B can be used as an antitumorigenic agent and may be exploited in cancer chemotherapy. ? 2008 American Chemical Society.
|DOI:||10.1021/pr700742h||metadata.dc.subject.other:||aurovertin; aurovertin b; unclassified drug; 3,3',4,5'-tetrahydroxystilbene; ATP5B protein, human; aurovertin; aurovertin b; enzyme inhibitor; membrane protein; piceatannol; proton transporting adenosine triphosphate synthase; resveratrol; stilbene derivative; antineoplastic activity; article; breast carcinoma; cancer cell; cancer chemotherapy; cancer tissue; controlled study; drug efficacy; drug mechanism; drug research; drug targeting; gene expression; human; human tissue; nucleotide sequence; priority journal; protein analysis; protein expression; apoptosis; breast tumor; cell line; cell proliferation; cell survival; chemical structure; drug antagonism; drug effect; enzymology; female; IC 50; metabolism; pathology; tumor cell line; upregulation; Apoptosis; Aurovertins; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Membrane Proteins; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Stilbenes; Up-Regulation
|Appears in Collections:||生命科學系|
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